The leishmaniases are diseases caused by pathogenic protozoan parasites of the genus
Leishmania. Infections are initiated when a sand fly vector inoculates Leishmania parasites …

Kinetoplastids branched early from the eukaryotic lineage and include several parasitic
protozoan species. Up to several hundred kinetoplastid genes are co-transcribed into …

Leishmania parasites cause a spectrum of clinical pathology in humans ranging from
disfiguring cutaneous lesions to fatal visceral leishmaniasis. We have generated a reference …

Trypanosomes are eukaryotic, unicellular parasites, such as Trypanosoma brucei, which
causes sleeping sickness, and Trypanosoma cruzi, which causes Chagas disease …

The protozoan parasite Trypanosoma cruzi has a complex life cycle characterized by
intracellular and extracellular forms alternating between invertebrate and mammals. To cope …

We report a global quantitative phosphoproteomic study of bloodstream and procyclic form
Trypanosoma brucei using SILAC labeling of each lifecycle stage. Phosphopeptide …

While gene expression is a fundamental and tightly controlled cellular process that is
regulated at multiple steps, the exact contribution of each step remains unknown in any …

Background The transition from prokaryotes to eukaryotes was the most radical change in
cell organisation since life began, with the largest ever burst of gene duplication and novelty …

The protozoan parasite Trypanosoma brucei has a complex digenetic lifecycle between a
mammalian host and an insect vector, and adaption of its proteome between lifecycle stages …

Background Trypanosoma brucei subspecies infect humans and animals in sub-Saharan
Africa. This early diverging eukaryote shows many novel features in basic biological …