Cell motility in cancer invasion and metastasis: insights from simple model organisms
CH Stuelten, CA Parent, DJ Montell - Nature Reviews Cancer, 2018 - nature.com
Metastasis remains the greatest challenge in the clinical management of cancer. Cell motility
is a fundamental and ancient cellular behaviour that contributes to metastasis and is …
is a fundamental and ancient cellular behaviour that contributes to metastasis and is …
Basement membranes: cell scaffoldings and signaling platforms
PD Yurchenco - Cold Spring Harbor perspectives in …, 2011 - cshperspectives.cshlp.org
Basement membranes are widely distributed extracellular matrices that coat the basal
aspect of epithelial and endothelial cells and surround muscle, fat, and Schwann cells …
aspect of epithelial and endothelial cells and surround muscle, fat, and Schwann cells …
OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes
OrthoList, a compendium of Caenorhabditis elegans genes with human orthologs compiled
in 2011 by a meta-analysis of four orthology-prediction methods, has been a popular tool for …
in 2011 by a meta-analysis of four orthology-prediction methods, has been a popular tool for …
Matrix metalloproteinases and the regulation of tissue remodelling
Matrix metalloproteinases (MMPs) were discovered because of their role in amphibian
metamorphosis, yet they have attracted more attention because of their roles in disease …
metamorphosis, yet they have attracted more attention because of their roles in disease …
Basement membranes in development and disease
R Sekiguchi, KM Yamada - Current topics in developmental biology, 2018 - Elsevier
The basement membrane is a thin but dense, sheet-like specialized type of extracellular
matrix that has remarkably diverse functions tailored to individual tissues and organs. Tightly …
matrix that has remarkably diverse functions tailored to individual tissues and organs. Tightly …
Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology
The nematode Caenorhabditis elegans has emerged as an important animal model in
various fields including neurobiology, developmental biology, and genetics. Characteristics …
various fields including neurobiology, developmental biology, and genetics. Characteristics …
Molecular circuits shared by placental and cancer cells, and their implications in the proliferative, invasive and migratory capacities of trophoblasts
C Ferretti, L Bruni, V Dangles-Marie… - Human reproduction …, 2007 - academic.oup.com
Trophoblast research over the past decades has underlined the striking similarities between
the proliferative, migratory and invasive properties of placental cells and those of cancer …
the proliferative, migratory and invasive properties of placental cells and those of cancer …
Comprehensive endogenous tagging of basement membrane components reveals dynamic movement within the matrix scaffolding
Basement membranes (BMs) are supramolecular matrices built on laminin and type IV
collagen networks that provide structural and signaling support to tissues. BM complexity …
collagen networks that provide structural and signaling support to tissues. BM complexity …
A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis
X Ma, Z Zhao, L Xiao, W Xu, Y Kou, Y Zhang, G Wu… - Nature …, 2021 - nature.com
Complex biological processes such as embryogenesis require precise coordination of cell
differentiation programs across both space and time. Using protein-fusion fluorescent …
differentiation programs across both space and time. Using protein-fusion fluorescent …
Adaptive F-actin polymerization and localized ATP production drive basement membrane invasion in the absence of MMPs
Matrix metalloproteinases (MMPs) are associated with decreased patient prognosis but
have failed as anti-invasive drug targets despite promoting cancer cell invasion. Through …
have failed as anti-invasive drug targets despite promoting cancer cell invasion. Through …