Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA
damage are DNA double-strand breaks (DSBs), which can cause cell lethality if unrepaired …

Mating type in Saccharomyces cerevisiae is determined by two nonhomologous alleles,
MAT a and MAT α. These sequences encode regulators of the two different haploid mating …

Genomes are subject to constant threat by damaging agents that generate DNA double-
strand breaks (DSBs). The ends of linear chromosomes need to be protected from DNA …

DNA double-strand breaks (DSBs) are dangerous lesions that if not properly repaired can
lead to genomic change or cell death. Organisms have developed several pathways and …

The DNA-damage response (DDR) arrests cell-cycle progression until damage is removed.
DNA-damage-induced cellular senescence is associated with persistent DDR. The …

The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

A single double-strand break (DSB) induced by HO endonuclease triggers both repair by
homologous recombination and activation of the Mec1-dependent DNA damage checkpoint …

Telomeres allow cells to distinguish natural chromosome ends from damaged DNA. When
telomere function is disrupted, a potentially lethal DNA damage response can ensue, DNA …

▪ Abstract Telomeres are essential for genome stability in all eukaryotes. Changes in
telomere functions and the associated chromosomal abnormalities have been implicated in …

The Mre11 complex is a multisubunit nuclease that is composed of Mre11, Rad50 and
Nbs1/Xrs2. Mutations in the genes that encode components of this complex result in DNA …