Association of glycemic indices (hyperglycemia, glucose variability, and hypoglycemia) with oxidative stress and diabetic complications

E Papachristoforou, V Lambadiari… - Journal of diabetes …, 2020 - Wiley Online Library
Oxidative stress (OS) is defined as a disturbance in the prooxidant‐antioxidant balance of
the cell, in favor of the former, which results in the antioxidant capacity of the cell to be …

Glucagon-like peptide-1 receptor: mechanisms and advances in therapy

Z Zheng, Y Zong, Y Ma, Y Tian, Y Pang… - … and Targeted Therapy, 2024 - nature.com
Abstract The glucagon-like peptide-1 (GLP-1) receptor, known as GLP-1R, is a vital
component of the G protein-coupled receptor (GPCR) family and is found primarily on the …

Glycaemic variability in diabetes: clinical and therapeutic implications

A Ceriello, L Monnier, D Owens - The lancet Diabetes & …, 2019 - thelancet.com
Glycaemic variability is an integral component of glucose homoeostasis. Although it has not
yet been definitively confirmed as an independent risk factor for diabetes complications …

[HTML][HTML] Reactive oxygen species in inflammation and tissue injury

SM Rizwan, P ReddySekhar… - Antioxidants & redox …, 2014 - liebertpub.com
Reactive oxygen species (ROS) are key signaling molecules that play an important role in
the progression of inflammatory disorders. An enhanced ROS generation by …

Glycaemic management in diabetes: old and new approaches

A Ceriello, F Prattichizzo, M Phillip, IB Hirsch… - The lancet Diabetes & …, 2022 - thelancet.com
HbA 1c is the most used parameter to assess glycaemic control. However, evidence
suggests that the concept of hyperglycaemia has profoundly changed and that different …

[HTML][HTML] Update on the treatment of type 2 diabetes mellitus

JJ Marín-Peñalver, I Martín-Timón… - World journal of …, 2016 - ncbi.nlm.nih.gov
To achieve good metabolic control in diabetes and keep long term, a combination of
changes in lifestyle and pharmacological treatment is necessary. Achieving near-normal …

Glucose variability: how does it work?

VV Klimontov, OV Saik, AI Korbut - International journal of molecular …, 2021 - mdpi.com
A growing body of evidence points to the role of glucose variability (GV) in the development
of the microvascular and macrovascular complications of diabetes. In this review, we …

Glycemic variability and oxidative stress: a link between diabetes and cardiovascular disease?

Y Saisho - International journal of molecular sciences, 2014 - mdpi.com
Diabetes is associated with a two to three-fold increase in risk of cardiovascular disease.
However, intensive glucose-lowering therapy aiming at reducing HbA1c to a near-normal …

Glucagon-like peptide 1 reduces endothelial dysfunction, inflammation, and oxidative stress induced by both hyperglycemia and hypoglycemia in type 1 diabetes

A Ceriello, A Novials, E Ortega, S Canivell… - Diabetes …, 2013 - Am Diabetes Assoc
OBJECTIVE Hyperglycemia and hypoglycemia currently are considered risk factors for
cardiovascular disease in type 1diabetes. Both acute hyperglycemia and hypoglycemia …

Issues of cardiovascular risk management in people with diabetes in the COVID-19 era

A Ceriello, E Standl, D Catrinoiu, B Itzhak… - Diabetes …, 2020 - Am Diabetes Assoc
People with diabetes compared with people without exhibit worse prognosis if affected by
coronavirus disease 2019 (COVID-19) induced by the severe acute respiratory syndrome …