Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Abstract N-methyl-D-aspartate (NMDA) receptors mediate a slow component of excitatory
synaptic transmission, are widely distributed throughout the central nervous system, and …

The delivery of a drug to a specific organ or tissue at an efficacious concentration is the
pharmacokinetic (PK) hallmark of promoting effective pharmacological action at a target site …

Abstract l-glutamate is an excitatory neurotransmitter in the central nervous system (CNS),
which can activate ionotropic receptors (iGluRs) and metabotropic (mGluRs) receptors. N …

The iridium-catalyzed enantioselective coupling reaction of vinyl azides and allylic
electrophiles is presented and provides access to β-chiral carbonyl derivatives. Vinyl azides …

Ion channels have been characterized as promising drug targets for treatment of numerous
human diseases. Functions of ion channels can be fine-tuned by allosteric modulators …

A series of tryptamine derivatives has been designed and synthesized as novel GluN2B
subunit-containing NMDA receptor (GluN2B-NMDAR) antagonists, which could …

Rationale The rapid-onset and long-lasting antidepressant properties of ketamine have
prompted investigations into a variety of agents that target N-methyl-D-aspartate receptors …

The pH-dependent solubility of the weakly basic TYK2 inhibitor 1 posed a risk to its
advancement, given that drugs with such profiles have exhibited drug–drug interaction (DDI) …

The phosphate prodrug approach has emerged as a viable option for increasing the
bioavailability of a drug candidate with low hydrophilicity and poor cell membrane …