Protein phosphatases act as key regulators of multiple important cellular processes and are
attractive therapeutic targets for various diseases. Although extensive effort has been …

This Perspective focuses on thiol-mediated uptake, that is, the entry of substrates into cells
enabled by oligochalcogenides or mimics, often disulfides, and inhibited by thiol-reactive …

Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a
multitude of mammalian cell types. This review covers recent advances on specific functions …

Vitamin D deficiency has been linked to many human diseases such as Alzheimer's disease
(AD), Parkinson's disease (PD), multiple sclerosis (MS), hypertension and cardiovascular …

Alzheimer's disease (AD) extracts a heavy societal toll. The value of medical advances that
delay onset of AD could be significant. Using data from nationally representative samples …

Protein tyrosine phosphatases (PTPs) are a family of enzymes essential for numerous
cellular processes, and several PTPs have been validated as therapeutic targets for human …

Diabetes and obesity are commonly associated with Alzheimer's disease (AD).
Accumulating evidence show that insulin signaling defects are protentional upstream driver …

Hydrogen sulfide (H 2 S) and hydrogen polysulfides (H 2 S n) are essential regulatory
signaling molecules generated by the entire body, including the central nervous system …

Evidence from neuropathological, genetic, animal model, and biochemical studies has
indicated that the accumulation of amyloid‐beta (Aβ) is associated with, and probably …

Alzheimer's disease is a global public health problem and the most common form of
dementia. Due to the failure of many single therapies targeting the two hallmarks, Aβ and …