Targeting protein phosphatases in cancer immunotherapy and autoimmune disorders
SM Stanford, N Bottini - Nature Reviews Drug Discovery, 2023 - nature.com
Protein phosphatases act as key regulators of multiple important cellular processes and are
attractive therapeutic targets for various diseases. Although extensive effort has been …
attractive therapeutic targets for various diseases. Although extensive effort has been …
Thiol-mediated uptake
This Perspective focuses on thiol-mediated uptake, that is, the entry of substrates into cells
enabled by oligochalcogenides or mimics, often disulfides, and inhibited by thiol-reactive …
enabled by oligochalcogenides or mimics, often disulfides, and inhibited by thiol-reactive …
Functions of p38 MAP kinases in the central nervous system
Mitogen-activated protein (MAP) kinases are a central component in signaling networks in a
multitude of mammalian cell types. This review covers recent advances on specific functions …
multitude of mammalian cell types. This review covers recent advances on specific functions …
Vitamin D cell signalling in health and disease
MJ Berridge - Biochemical and biophysical research communications, 2015 - Elsevier
Vitamin D deficiency has been linked to many human diseases such as Alzheimer's disease
(AD), Parkinson's disease (PD), multiple sclerosis (MS), hypertension and cardiovascular …
(AD), Parkinson's disease (PD), multiple sclerosis (MS), hypertension and cardiovascular …
The value of delaying Alzheimer's disease onset
J Zissimopoulos, E Crimmins… - Forum for Health …, 2015 - degruyter.com
Alzheimer's disease (AD) extracts a heavy societal toll. The value of medical advances that
delay onset of AD could be significant. Using data from nationally representative samples …
delay onset of AD could be significant. Using data from nationally representative samples …
Targeting tyrosine phosphatases: time to end the stigma
SM Stanford, N Bottini - Trends in Pharmacological Sciences, 2017 - cell.com
Protein tyrosine phosphatases (PTPs) are a family of enzymes essential for numerous
cellular processes, and several PTPs have been validated as therapeutic targets for human …
cellular processes, and several PTPs have been validated as therapeutic targets for human …
FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling
H Li, Y Ren, K Mao, F Hua, Y Yang, N Wei… - Biochemical and …, 2018 - Elsevier
Diabetes and obesity are commonly associated with Alzheimer's disease (AD).
Accumulating evidence show that insulin signaling defects are protentional upstream driver …
Accumulating evidence show that insulin signaling defects are protentional upstream driver …
Protein S-sulfhydration: unraveling the prospective of hydrogen sulfide in the brain, vasculature and neurological manifestations
Hydrogen sulfide (H 2 S) and hydrogen polysulfides (H 2 S n) are essential regulatory
signaling molecules generated by the entire body, including the central nervous system …
signaling molecules generated by the entire body, including the central nervous system …
Amyloid‐β‐Induced Dysregulation of AMPA Receptor Trafficking
Evidence from neuropathological, genetic, animal model, and biochemical studies has
indicated that the accumulation of amyloid‐beta (Aβ) is associated with, and probably …
indicated that the accumulation of amyloid‐beta (Aβ) is associated with, and probably …
Moringa oleifera alleviates Aβ burden and improves synaptic plasticity and cognitive impairments in APP/PS1 mice
YAR Mahaman, J Feng, F Huang, MTM Salissou… - Nutrients, 2022 - mdpi.com
Alzheimer's disease is a global public health problem and the most common form of
dementia. Due to the failure of many single therapies targeting the two hallmarks, Aβ and …
dementia. Due to the failure of many single therapies targeting the two hallmarks, Aβ and …