The gut microbiota shows a wide inter-individual variation, but its within-individual variation
is relatively stable over time. A functional core microbiome, provided by abundant bacterial …

The gastrointestinal tract has recently come to the forefront of multiple research fields. It is
now recognized as a major source of signals modulating food intake, insulin secretion and …

The view that sleep is essential for survival is supported by the ubiquity of this behavior, the
apparent existence of sleep-like states in the earliest animals, and the fact that severe sleep …

Aging is a major risk factor for a number of chronic diseases, including neurodegenerative
and cerebrovascular disorders. Aging processes have therefore been discussed as potential …

Diet has a profound effect on tissue regeneration in diverse organisms, and low caloric
states such as intermittent fasting have beneficial effects on organismal health and age …

The licensed drug rapamycin has potential to be repurposed for geroprotection. A key
challenge is to avoid adverse side effects from continuous dosing. Here we show that …

Sex differences in longevity can provide insights into novel mechanisms of aging, yet they
have been little studied. Surprisingly, sex-specific longevity patterns are best known in wild …

Alterations in the composition of the intestinal microbiota have been correlated with aging
and measures of frailty in the elderly. However, the relationships between microbial …

Adult tissue stem cells have a pivotal role in tissue maintenance and regeneration
throughout the lifespan of multicellular organisms. Loss of tissue homeostasis during post …

All multicellular organisms undergo a decline in tissue and organ function as they age. An
attractive theory is that a loss in stem cell number and/or activity over time causes this …