Current and emerging therapies for limbal stem cell deficiency
The corneal epithelium serves to protect the underlying cornea from the external
environment and is essential for corneal transparency and optimal visual function …
environment and is essential for corneal transparency and optimal visual function …
Wnt/β-catenin signaling in corneal epithelium development, homeostasis, and pathobiology
Y Wang, H Ge, P Chen, Y Wang - Experimental Eye Research, 2024 - Elsevier
The corneal epithelium is located on the most anterior surface of the eyeball and protects
against external stimuli. The development of the corneal epithelium and the maintenance of …
against external stimuli. The development of the corneal epithelium and the maintenance of …
[HTML][HTML] Limbal BCAM expression identifies a proliferative progenitor population capable of holoclone formation and corneal differentiation
The corneal epithelium is renowned for high regenerative potential, which is dependent on
the coordinated function of its diverse progenitor subpopulations. However, the molecular …
the coordinated function of its diverse progenitor subpopulations. However, the molecular …
[HTML][HTML] Process development and safety evaluation of ABCB5+ limbal stem cells as advanced-therapy medicinal product to treat limbal stem cell deficiency
A Norrick, J Esterlechner, E Niebergall-Roth… - Stem Cell Research & …, 2021 - Springer
Background While therapeutic success of the limbal tissue or cell transplantation to treat
severe cases of limbal stem cell (LSC) deficiency (LSCD) strongly depends on the …
severe cases of limbal stem cell (LSC) deficiency (LSCD) strongly depends on the …
[HTML][HTML] Human iPS cells engender corneal epithelial stem cells with holoclone-forming capabilities
S Watanabe, R Hayashi, Y Sasamoto, M Tsujikawa… - Iscience, 2021 - cell.com
Human induced pluripotent stem cells (hiPSCs) can generate a multiplicity of organoids, yet
no compelling evidence currently exists as to whether or not these contain tissue-specific …
no compelling evidence currently exists as to whether or not these contain tissue-specific …
High expression of SARS-CoV2 viral entry-related proteins in human limbal stem cells
Y Sasamoto, CAA Lee, M Yoshihara, G Martin… - The Ocular Surface, 2022 - Elsevier
Abstract Purpose Coronavirus disease 2019 (COVID-19) is caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV2). While the ocular surface is considered …
respiratory syndrome coronavirus 2 (SARS-CoV2). While the ocular surface is considered …
[HTML][HTML] Protocol for isolating human BCAM-positive corneal progenitor cells by flow cytometry and cell sorting
BCAM-positive basal limbal epithelial cells are an early transit-amplifying cell population
(TAC) capable of holoclone formation and corneal epithelial differentiation. Here, we present …
(TAC) capable of holoclone formation and corneal epithelial differentiation. Here, we present …