Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to
growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of …

Herein we will review the role of glycans in the immune system. Specific topics covered
include: the glycosylation sites of IgE, IgM, IgD, IgE, IgA, and IgG; how glycans can encode …

Protein glycosylation is a ubiquitous post-translational modification found in all domains of
life. Despite their significant complexity in animal systems, glycan structures have crucial …

Protein glycosylation and other post-translational modifications are involved in potentially all
aspects of human growth and development. Defective glycosylation has adverse effects on …

Glycosylation is crucial in cellular metabolism and survival. Of interest is the role of N-linked
and O-linked glycans in disease states. Robust analytical methods must be defined to …

Photodissociation mass spectrometry combines the ability to activate and fragment ions
using photons with the sensitive detection of the resulting product ions by mass …

Glycosylation is a common posttranslational modification of proteins and lipids of the
secretory pathway that generates binding sites for galactose-specific lectins or galectins …

Alteration in glycosylation has been observed in cancer. However, monitoring glycosylation
changes during breast cancer progression is difficult in humans. In this study, we used a well …

Inflammaging is a recent theory of aging originally proposed in 2000 where data and
conceptualizations regarding the aging of the immune system (immunosenescence) and the …

Metastasis accounts for the majority of cancer-associated mortalities, representing a huge
health and economic burden. One of the mechanisms that enables metastasis is …