Insights into the role of sialylation in cancer progression and metastasis
C Dobie, D Skropeta - British Journal of Cancer, 2021 - nature.com
Upregulation of sialyltransferases—the enzymes responsible for the addition of sialic acid to
growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of …
growing glycoconjugate chains—and the resultant hypersialylation of up to 40–60% of …
[HTML][HTML] Glycans in the immune system and the altered glycan theory of autoimmunity: a critical review
E Maverakis, K Kim, M Shimoda, ME Gershwin… - Journal of …, 2015 - Elsevier
Herein we will review the role of glycans in the immune system. Specific topics covered
include: the glycosylation sites of IgE, IgM, IgD, IgE, IgA, and IgG; how glycans can encode …
include: the glycosylation sites of IgE, IgM, IgD, IgE, IgA, and IgG; how glycans can encode …
Vertebrate protein glycosylation: diversity, synthesis and function
KW Moremen, M Tiemeyer, AV Nairn - Nature reviews Molecular cell …, 2012 - nature.com
Protein glycosylation is a ubiquitous post-translational modification found in all domains of
life. Despite their significant complexity in animal systems, glycan structures have crucial …
life. Despite their significant complexity in animal systems, glycan structures have crucial …
Glycans and glycoproteins as specific biomarkers for cancer
Protein glycosylation and other post-translational modifications are involved in potentially all
aspects of human growth and development. Defective glycosylation has adverse effects on …
aspects of human growth and development. Defective glycosylation has adverse effects on …
Current Methods for the Characterization of O-Glycans
H Wilkinson, R Saldova - Journal of proteome research, 2020 - ACS Publications
Glycosylation is crucial in cellular metabolism and survival. Of interest is the role of N-linked
and O-linked glycans in disease states. Robust analytical methods must be defined to …
and O-linked glycans in disease states. Robust analytical methods must be defined to …
Photodissociation mass spectrometry: new tools for characterization of biological molecules
JS Brodbelt - Chemical Society Reviews, 2014 - pubs.rsc.org
Photodissociation mass spectrometry combines the ability to activate and fragment ions
using photons with the sensitive detection of the resulting product ions by mass …
using photons with the sensitive detection of the resulting product ions by mass …
Glycosylation, galectins and cellular signaling
Glycosylation is a common posttranslational modification of proteins and lipids of the
secretory pathway that generates binding sites for galactose-specific lectins or galectins …
secretory pathway that generates binding sites for galactose-specific lectins or galectins …
High-mannose glycans are elevated during breast cancer progression
MLA De Leoz, LJT Young, HJ An… - Molecular & Cellular …, 2011 - ASBMB
Alteration in glycosylation has been observed in cancer. However, monitoring glycosylation
changes during breast cancer progression is difficult in humans. In this study, we used a well …
changes during breast cancer progression is difficult in humans. In this study, we used a well …
Inflammaging and human longevity in the omics era
D Monti, R Ostan, V Borelli, G Castellani… - Mechanisms of Ageing …, 2017 - Elsevier
Inflammaging is a recent theory of aging originally proposed in 2000 where data and
conceptualizations regarding the aging of the immune system (immunosenescence) and the …
conceptualizations regarding the aging of the immune system (immunosenescence) and the …
[HTML][HTML] Recent advances in the development of sialyltransferase inhibitors to control cancer metastasis: A comprehensive review
Metastasis accounts for the majority of cancer-associated mortalities, representing a huge
health and economic burden. One of the mechanisms that enables metastasis is …
health and economic burden. One of the mechanisms that enables metastasis is …