Radiotherapy (RT) is an effective treatment option for cancer patients, which induces the
production of reactive oxygen species (ROS) and causes oxidative stress (OS), leading to …

Immunotherapy is an effective treatment option that revolutionizes the management of
various cancers. Nevertheless, only a subset of patients receiving immunotherapy exhibit …

The impact of bone cell activation on bacterially-induced osteolysis remains elusive. Here,
we show that matrix-embedded osteocytes stimulated with bacterial pathogen-associated …

Abstract Background Cancer-associated fibroblasts (CAFs), one of the major components of
the tumor stroma, contribute to an immunosuppressive tumor microenvironment (TME) …

Tumor microenvironment (TME) can serve as the 'soil'for the growth and survival of tumor
cells and function synergically with tumor cells to mediate tumor progression and therapeutic …

PDZ and LIM domains-containing proteins play pivotal functions in cell cytoskeleton
organization, cell polarization and differentiation. As a key member of the family, PDLIM2 …

BTB and CNC homology 1 (Bach1) is a protein that forms nuclear heterodimers with the
small musculoaponeurotic fibrosarcoma (sMaf). These bind to genomic DNA, promoting the …

Immune checkpoint inhibitors (ICIs) and their combination with other therapies such as
chemotherapy, fail in most cancer patients. We previously identified the PDZ-LIM domain …

Transcription factor BTB domain and CNC homology 1 (BACH1) belongs to the Cap 'n'Collar
and basic region Leucine Zipper (CNC-bZIP) family. BACH1 is widely expressed in …

Alveolar macrophages are pivotal components of the lung's innate immune defense against
respiratory virus infections. Their multifaceted role spans from viral clearance to modulation …