Objective To summarize recent scientific advances in protein-derived soluble biomarkers of
osteoarthritis. Design A systematic search on the PubMed electronic database of clinical …

Macromolecular therapeutics of biological origin, also known as biologics, have become
one of the fastest-growing classes of drugs for management of a range of chronic and acute …

Osteoarthritis (OA) is the most common chronic degenerative joint disease which causes
substantial joint pain, deformity and loss of activities of daily living. Currently, there are over …

Conventional radiography remains the most widely available imaging modality in clinical
practice in knee osteoarthritis. Recent research has been carried out to develop novel …

In recent years, markers research has focused on the structural components of cartilage
matrix. Specifically, a second generation of degradation markers has been developed …

Connective tissue (ConT) remodeling is an essential process in tissue regeneration, where
a balanced replacement of old tissue by new tissue occurs. This balance is disturbed in …

Objective Osteoarthritis (OA) is characterized by the gradual loss of cartilage. Sprifermin, a
recombinant FGF18, is being developed as a cartilage anabolic drug. PRO-C2 is a serum …

Background: Menopause is associated with detrimental changes in turnover of bone and
cartilage and a variety of symptoms with negative impact on the quality of life. Naturally …

Objective To investigate acute changes in biochemical markers of cartilage turnover in
response to moderate intensity exercise with and without joint impact in humans with knee …

Objectives: The objective of this cross-sectional study was to explore the associations
between single-question VAS pain and the weight-bearing and non–weight-bearing …