Melatonin is a ubiquitous molecule present in almost every live being from bacteria to
humans. In vertebrates, besides being produced in peripheral tissues and acting as an …

Despite considerable advances in the past few years, obesity and type 2 diabetes mellitus
(T2DM) remain two major challenges for public health systems globally. In the past 9 years …

Almost all living organisms have evolved autoregulatory transcriptional‐translational
feedback loops that produce oscillations with a period of approximately 24‐h. These …

Choroidal neovascularization (CNV) is an important characteristic of advanced wet age‐
related macular degeneration (AMD) and leads to severe visual impairment among elderly …

In type 2 diabetes mellitus (T2DM) and its related disorders like obesity, the abnormal
protein processing, oxidative stress and proinflammatory cytokines will drive the activation of …

Melatonin, a hormone synthesized by both the pineal gland and retina, functions as an
important modulator of a number of physiological functions. In addition to its rather well …

Obesity is a predominant risk factor in ischemic stroke and is commonly comorbid with it.
Pathologies following these conditions are associated with systemic and local inflammation …

Melatonin, a circadian hormone, has been reported to improve host lipid metabolism by
reprogramming the gut microbiota, which also exhibits rhythmicity in a light/dark cycle …

Diabetes mellitus (DM) and diabetes-related complications are amongst the leading causes
of mortality worldwide. The international diabetes federation (IDF) has estimated 592 million …

The basic pathophysiological mechanisms underlying septic cardiomyopathy have not yet
been completely clarified. Disease-specific treatments are lacking, and care is still based on …