Genome-wide association study (GWAS) is the most popular approach to dissecting
complex traits in plants, humans, and animals. Numerous methods and tools have been …

When analyzing the spatio-temporal dependence in most environmental and earth sciences
variables such as pollutant concentrations at different levels of the atmosphere, a special …

Imprinted genes, giving rise to parent-of-origin effects (POEs), have been hypothesised to
affect type 1 diabetes (T1D) and rheumatoid arthritis (RA). However, maternal effects may …

Motivation The use and functionality of Electronic Health Records (EHR) have increased
rapidly in the past few decades. EHRs are becoming an important depository of patient …

The estimation of heritability has been an important question in statistical genetics. Due to
the clear mathematical properties, the modified Haseman–Elston regression has been found …

Background Variability of response to medication is a well-known phenomenon, determined
by both environmental and genetic factors. Understanding the heritable component of the …

Biomarkers may be useful endophenotypes for genetic studies if they share genetic sources
of variation with the outcome, for example, with all-cause mortality. Australian adult study …

Identifying the relationship between genotype and phenotype is a fundamental question of
broad interest that has proven tremendously difficult to solve, partly due to the requirement …

Diseases are the result of genetic and/or environmental factors. Understanding the etiology
of human disease is necessary to advance precision medicine. Pedigree analysis is a …

A class of epigenetic inheritance patterns known as genomic imprinting allows alleles to
influence the phenotype in a parent-of-origin-specific manner. Various pedigree-based …