Thirty-five years of research on p53 gave rise to more than 68,000 articles and reviews, but
did not allow the uncovering of all the mysteries that this major tumor suppressor holds. How …

The International Agency for Research on Cancer (IARC) has recently reported a 66%
increase in the global number of cancer deaths since 1960. In the US alone, about one in …

Objective The aim of this article is to discuss mutant p53 as a possible therapeutic target and
biomarker for breast cancer. Results TP53 (p53) is the most frequently mutated gene in …

Ribosomes are specialized entities that participate in regulation of gene expression through
their rRNAs carrying ribozyme activity. Ribosome biogenesis is overactivated in p53 …

Breast cancer is the most frequent invasive tumor diagnosed in women, causing over 400
000 deaths yearly worldwide. Like other tumors, it is a disease with a complex …

More than 95% of the 20,000 to 25,000 transcribed human genes undergo alternative RNA
splicing, which increases the diversity of the proteome. Isoforms derived from the same gene …

Alternative splicing has critical roles in normal development and can promote growth and
survival in cancer. Aberrant splicing, the production of noncanonical and cancer-specific …

In this review we focus on the major isoforms of the tumor-suppressor protein p53,
dysfunction of which often leads to cancer. Mutations of the TP53 gene, particularly in the …

It is poorly understood how a single protein, p53, can be responsive to so many stress
signals and orchestrates very diverse cell responses to maintain/restore cell/tissue functions …

Although it is one of the most studied proteins, p53 continues to be an enigma. This protein
has numerous biological functions, possesses intrinsically disordered regions crucial for its …