Cyclic adenosine monophosphate (cAMP) is the first discovered second messenger, which
plays pivotal roles in cell signaling, and regulates many physiological and pathological …

The field of cAMP signaling is witnessing exciting developments with the recognition that
cAMP is compartmentalized and that spatial regulation of cAMP is critical for faithful signal …

Cancer is one of the most common causes of death globally. Despite extensive research
and considerable advances in cancer therapy, the fundamentals of the disease remain …

Nearly all breast cancer deaths result from metastatic disease. Despite this, the genomic
events that drive metastatic recurrence are poorly understood. We performed whole-exome …

Cyclic nucleotide phosphodiesterases (PDEs) modulate the neurohormonal regulation of
cardiac function by degrading cAMP and cGMP. In cardiomyocytes, multiple PDE isozymes …

Abstract The phosphodiesterase 4 (PDE4) enzyme family plays a pivotal role in regulating
levels of the second messenger cAMP. Consequently, PDE4 inhibitors have been …

Many of the fundamental concepts of signal transduction and kinase activity are attributed to
the discovery and crystallization of cAMP-dependent protein kinase, or protein kinase A …

The primary cilium projects from the surface of most vertebrate cells, where it senses
extracellular signals to regulate diverse cellular processes during tissue development and …

Cyclic nucleotides (cAMP, cGMP) play a major role in normal and pathologic signaling.
Beyond receptors, cyclic nucleotide phosphodiesterases;(PDEs) rapidly convert the cyclic …

Background: The cyclic AMP (adenosine monophosphate; cAMP)-hydrolyzing protein
PDE4B (phosphodiesterase 4B) is a key negative regulator of cardiac β-adrenergic receptor …