To understand complex biological systems requires the integration of experimental and
computational research—in other words a systems biology approach. Computational …

Comparisons of rhythmic movements and the central pattern generators (CPGs) that control
them uncover principles about the evolution of behaviour and neural circuits. Over the …

Animal behaviour is often quantified through subjective, incomplete variables that mask
essential dynamics. Here, we develop a maximally predictive behavioural-state space from …

Highlights•The Caenorhabditis elegans motor circuit has a nearly complete connectome.•
Neurogenetic studies are unveiling a rich and complex set of signaling relationships …

The adoption of powerful software tools and computational methods from the software
industry by the scientific research community has resulted in a renewed interest in …

The exposure risk of 6-PPD quinone (6-PPDQ) has aroused increasing concern. In the
natural environment, 6-PPDQ could interact with other pollutants, posing more severe …

Highlights•Analysis of small oscillatory circuits reveals variability in system
parameters.•Circuits with different parameter sets can be robust to moderate …

A complete understanding of the brain requires an integrated description of the numerous
scales and levels of neural organization. This means studying the interplay of genes and …

OpenWorm is an international collaboration with the aim of understanding how the behavior
of Caenorhabditis elegans (C. elegans) emerges from its underlying physiological …

Cell-or network-driven oscillators underlie motor rhythmicity. The identity of C. elegans
oscillators remains unknown. Through cell ablation, electrophysiology, and calcium imaging …