EGFR in cancer: Signaling mechanisms, drugs, and acquired resistance
ML Uribe, I Marrocco, Y Yarden - Cancers, 2021 - mdpi.com
Simple Summary Growth factors are hormone-like molecules able to promote division and
migration of normal cells, but cancer captured the underlying mechanisms to unleash tumor …
migration of normal cells, but cancer captured the underlying mechanisms to unleash tumor …
All roads lead to directional cell migration
A Shellard, R Mayor - Trends in cell biology, 2020 - cell.com
Directional cell migration normally relies on a variety of external signals, such as chemical,
mechanical, or electrical, which instruct cells in which direction to move. Many of the major …
mechanical, or electrical, which instruct cells in which direction to move. Many of the major …
Steering cell migration: lamellipodium dynamics and the regulation of directional persistence
M Krause, A Gautreau - Nature reviews Molecular cell biology, 2014 - nature.com
Membrane protrusions at the leading edge of cells, known as lamellipodia, drive cell
migration in many normal and pathological situations. Lamellipodial protrusion is powered …
migration in many normal and pathological situations. Lamellipodial protrusion is powered …
The matrix environmental and cell mechanical properties regulate cell migration and contribute to the invasive phenotype of cancer cells
CT Mierke - Reports on Progress in Physics, 2019 - iopscience.iop.org
The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …
the nucleus. A closer look inside the cells reveals that there are functional compartments or …
Anisotropic forces from spatially constrained focal adhesions mediate contact guidance directed cell migration
Directed migration by contact guidance is a poorly understood yet vital phenomenon,
particularly for carcinoma cell invasion on aligned collagen fibres. We demonstrate that for …
particularly for carcinoma cell invasion on aligned collagen fibres. We demonstrate that for …
[HTML][HTML] Cell migration
Cell migration is fundamental to establishing and maintaining the proper organization of
multicellular organisms. Morphogenesis can be viewed as a consequence, in part, of cell …
multicellular organisms. Morphogenesis can be viewed as a consequence, in part, of cell …
Random versus directionally persistent cell migration
Directional migration is an important component of cell motility. Although the basic
mechanisms of random cell movement are well characterized, no single model explains the …
mechanisms of random cell movement are well characterized, no single model explains the …
Modeling tissue morphogenesis and cancer in 3D
KM Yamada, E Cukierman - Cell, 2007 - cell.com
Three-dimensional (3D) in vitro models span the gap between two-dimensional cell cultures
and whole-animal systems. By mimicking features of the in vivo environment and taking …
and whole-animal systems. By mimicking features of the in vivo environment and taking …
Adhesion signaling–crosstalk between integrins, Src and Rho
S Huveneers, EHJ Danen - Journal of cell science, 2009 - journals.biologists.com
Interactions between cells and the extracellular matrix coordinate signaling pathways that
control various aspects of cellular behavior. Integrins sense the physical properties of the …
control various aspects of cellular behavior. Integrins sense the physical properties of the …
Cell–matrix adhesion
AL Berrier, KM Yamada - Journal of cellular physiology, 2007 - Wiley Online Library
The complex interactions of cells with extracellular matrix (ECM) play crucial roles in
mediating and regulating many processes, including cell adhesion, migration, and signaling …
mediating and regulating many processes, including cell adhesion, migration, and signaling …