Highlights•Networks have been successfully applied in biology and medicine for several
decades.•Network methods play a key role in personalized and precision medicine.•Rapid …

Heart failure (HF) remains a major global health challenge, and more effective and
comprehensive plasma biomarkers are needed to effectively treat HF patients. Multiomics …

Background Biological age may be estimated by proteomic aging clocks (PACs). Previous
published PACs were constructed either in smaller studies or mainly in white individuals …

Background Oral manifestations function as precursors to potential systemic pathologies,
signaling early indicators of underlying health complications or immunological dysfunctions …

A common missense variant in ICAM1 among African American individuals (rs5491; pK56M)
has been associated with risk of heart failure with preserved ejection fraction (HFpEF), but …

Precision medicine aims to provide personalized clinical care guided by tools that reflect
underlying pathophysiology. The need for such an approach has never been greater in …

Background Previous studies have examined clinical predictors of incident heart failure (HF)
in men and women. However, potential mechanisms through which these clinical predictors …

Heart failure (HF) is one of the most common, complex, heterogeneous diseases in the
world, with over 1–3% of the global population living with the condition. Progression of HF …

Fully characterizing the genetic architecture of circulating proteins in multi-ancestry
populations provides an unprecedented opportunity to gain insights into the etiology of …

Solid organ transplants represent a major lifesaving procedure for tens of thousands of
Americans every year. While tissue typing and immunosuppressive agents have reduced …