[HTML][HTML] Manufacturing challenges and rational formulation development for AAV viral vectors
A Srivastava, KMG Mallela, N Deorkar… - Journal of pharmaceutical …, 2021 - Elsevier
Adeno-associated virus (AAV) has emerged as a leading platform for gene delivery for
treating various diseases due to its excellent safety profile and efficient transduction to …
treating various diseases due to its excellent safety profile and efficient transduction to …
[HTML][HTML] Vaccine instability in the cold chain: mechanisms, analysis and formulation strategies
OS Kumru, SB Joshi, DE Smith, CR Middaugh, T Prusik… - Biologicals, 2014 - Elsevier
Instability of vaccines often emerges as a key challenge during clinical development (lab to
clinic) as well as commercial distribution (factory to patient). To yield stable, efficacious …
clinic) as well as commercial distribution (factory to patient). To yield stable, efficacious …
Strategies for overcoming protein and peptide instability in biodegradable drug delivery systems
The global pharmaceutical market has recently shifted its focus from small molecule drugs to
peptide, protein, and nucleic acid drugs, which now comprise a majority of the top-selling …
peptide, protein, and nucleic acid drugs, which now comprise a majority of the top-selling …
Thermostable vaccines: An innovative concept in vaccine development
Introduction Vaccines represent he most common and safer ways of combating infectious
diseases. Loss of potency owing to thermal denaturation or degradation of almost all the …
diseases. Loss of potency owing to thermal denaturation or degradation of almost all the …
The science is there: key considerations for stabilizing viral vector-based Covid-19 vaccines
DJA Crommelin, DB Volkin, KH Hoogendoorn… - Journal of …, 2021 - Elsevier
Once Covid-19 vaccines become available, 5–10 billion vaccine doses should be globally
distributed, stored and administered. In this commentary, we discuss how this enormous …
distributed, stored and administered. In this commentary, we discuss how this enormous …
Rational design of thermostable vaccines by engineered peptide-induced virus self-biomineralization under physiological conditions
G Wang, RY Cao, R Chen, L Mo… - Proceedings of the …, 2013 - National Acad Sciences
The development of vaccines against infectious diseases represents one of the most
important contributions to medical science. However, vaccine-preventable diseases still …
important contributions to medical science. However, vaccine-preventable diseases still …
Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months
M Pelliccia, P Andreozzi, J Paulose… - Nature …, 2016 - nature.com
Up to 80% of the cost of vaccination programmes is due to the cold chain problem (that is,
keeping vaccines cold). Inexpensive, biocompatible additives to slow down the degradation …
keeping vaccines cold). Inexpensive, biocompatible additives to slow down the degradation …
Development of a thermostable microneedle patch for influenza vaccination
MJ Mistilis, AS Bommarius, MR Prausnitz - Journal of pharmaceutical …, 2015 - Elsevier
The goal of this study is to develop thermostable microneedle patch formulations for
influenza vaccine that can be partially or completely removed from the cold chain. During …
influenza vaccine that can be partially or completely removed from the cold chain. During …
Biomimetic mineralization: An emerging organism engineering strategy for biomedical applications
Z Nie, Y Zhang, R Tang, X Wang - Journal of Inorganic Biochemistry, 2022 - Elsevier
Biomineralization refers to a native biosynthesis process whereby the organisms fabricate
hierarchical organic-inorganic composites for life maintenance, growth, and biological …
hierarchical organic-inorganic composites for life maintenance, growth, and biological …
Towards tailored vaccine delivery: needs, challenges and perspectives
The ideal vaccine is a simple and stable formulation which can be conveniently
administered and provides life-long immunity against a given pathogen. The development of …
administered and provides life-long immunity against a given pathogen. The development of …