[HTML][HTML] Manufacturing challenges and rational formulation development for AAV viral vectors

A Srivastava, KMG Mallela, N Deorkar… - Journal of pharmaceutical …, 2021 - Elsevier
Adeno-associated virus (AAV) has emerged as a leading platform for gene delivery for
treating various diseases due to its excellent safety profile and efficient transduction to …

[HTML][HTML] Vaccine instability in the cold chain: mechanisms, analysis and formulation strategies

OS Kumru, SB Joshi, DE Smith, CR Middaugh, T Prusik… - Biologicals, 2014 - Elsevier
Instability of vaccines often emerges as a key challenge during clinical development (lab to
clinic) as well as commercial distribution (factory to patient). To yield stable, efficacious …

Strategies for overcoming protein and peptide instability in biodegradable drug delivery systems

M Shi, KJ McHugh - Advanced Drug Delivery Reviews, 2023 - Elsevier
The global pharmaceutical market has recently shifted its focus from small molecule drugs to
peptide, protein, and nucleic acid drugs, which now comprise a majority of the top-selling …

Thermostable vaccines: An innovative concept in vaccine development

R Kumar, V Srivastava, P Baindara… - Expert Review of …, 2022 - Taylor & Francis
Introduction Vaccines represent he most common and safer ways of combating infectious
diseases. Loss of potency owing to thermal denaturation or degradation of almost all the …

The science is there: key considerations for stabilizing viral vector-based Covid-19 vaccines

DJA Crommelin, DB Volkin, KH Hoogendoorn… - Journal of …, 2021 - Elsevier
Once Covid-19 vaccines become available, 5–10 billion vaccine doses should be globally
distributed, stored and administered. In this commentary, we discuss how this enormous …

Rational design of thermostable vaccines by engineered peptide-induced virus self-biomineralization under physiological conditions

G Wang, RY Cao, R Chen, L Mo… - Proceedings of the …, 2013 - National Acad Sciences
The development of vaccines against infectious diseases represents one of the most
important contributions to medical science. However, vaccine-preventable diseases still …

Additives for vaccine storage to improve thermal stability of adenoviruses from hours to months

M Pelliccia, P Andreozzi, J Paulose… - Nature …, 2016 - nature.com
Up to 80% of the cost of vaccination programmes is due to the cold chain problem (that is,
keeping vaccines cold). Inexpensive, biocompatible additives to slow down the degradation …

Development of a thermostable microneedle patch for influenza vaccination

MJ Mistilis, AS Bommarius, MR Prausnitz - Journal of pharmaceutical …, 2015 - Elsevier
The goal of this study is to develop thermostable microneedle patch formulations for
influenza vaccine that can be partially or completely removed from the cold chain. During …

Biomimetic mineralization: An emerging organism engineering strategy for biomedical applications

Z Nie, Y Zhang, R Tang, X Wang - Journal of Inorganic Biochemistry, 2022 - Elsevier
Biomineralization refers to a native biosynthesis process whereby the organisms fabricate
hierarchical organic-inorganic composites for life maintenance, growth, and biological …

Towards tailored vaccine delivery: needs, challenges and perspectives

JP Amorij, GFA Kersten, V Saluja, WF Tonnis… - Journal of Controlled …, 2012 - Elsevier
The ideal vaccine is a simple and stable formulation which can be conveniently
administered and provides life-long immunity against a given pathogen. The development of …