Hypertrophic cardiomyopathy: an up-to-date snapshot of the clinical drug development pipeline
J Tamargo, M Tamargo, R Caballero - Expert Opinion on …, 2022 - Taylor & Francis
Introduction Hypertrophic cardiomyopathy (HCM) is a complex cardiac disease with highly
variable phenotypic expression and clinical course most often caused by sarcomeric gene …
variable phenotypic expression and clinical course most often caused by sarcomeric gene …
MiR-497-5p regulates ox-LDL-induced dysfunction in vascular endothelial cells by targeting VEGFA/p38/MAPK pathway in atherosclerosis
W Lu, G Wan, H Zhu, T Zhu, X Zhang - Heliyon, 2024 - cell.com
Background The impairment of endothelial cells triggered by oxidized low-density
lipoprotein (ox-LDL) stands as a critical event in the advancement of atherosclerosis (AS) …
lipoprotein (ox-LDL) stands as a critical event in the advancement of atherosclerosis (AS) …
Postmortem analyses of myocardial microRNA expression in sepsis
P Lehto, S Skarp, T Saukko, H Säkkinen, H Syrjälä… - Scientific Reports, 2024 - nature.com
Background Sepsis can lead to myocardial depression, playing a significant role in sepsis
pathophysiology, clinical care, and outcome. To gain more insight into the pathophysiology …
pathophysiology, clinical care, and outcome. To gain more insight into the pathophysiology …
[HTML][HTML] MicroRNA profiling of the feline left heart identifies chamber-specific expression signatures in health and in advanced hypertrophic cardiomyopathy
J Joshua, JL Caswell, JMM Rodriguez, A Kipar… - Journal of Molecular and …, 2023 - Elsevier
Hypertrophic cardiomyopathy (HCM) is a common heart disease in humans and cats,
nonetheless, the disease pathogenesis is still poorly understood. MicroRNAs are suspected …
nonetheless, the disease pathogenesis is still poorly understood. MicroRNAs are suspected …
[HTML][HTML] Unveiling MicroRNA-124 as a biomarker in hypertrophic cardiomyopathy: An innovative approach using machine learning and intelligent data analysis
M Pisklova, G Osmak - International Journal of Cardiology, 2024 - Elsevier
Background Hypertrophic cardiomyopathy (HCM) is a widespread hereditary cardiac
pathology characterized by thickened heart walls and rearrangement of cardiomyocytes …
pathology characterized by thickened heart walls and rearrangement of cardiomyocytes …
Regulation of SMAD Signaling Pathway by miRNAs Associated with Myocardial Fibrosis: In silico Analysis of Target Gene Networks
M Pisklova, G Osmak, O Favorova - Biochemistry (Moscow), 2022 - Springer
Hypertrophic cardiomyopathy (HCM) is a hereditary heart disease caused by mutations in
the sarcomere genes, which is accompanied by myocardial fibrosis leading to progressive …
the sarcomere genes, which is accompanied by myocardial fibrosis leading to progressive …
Histone Modifications and miRNA Perturbations Contribute to Transcriptional Dysregulation of Hypertrophy in Obstructive Hypertrophic Cardiomyopathy
R Garmany, S Dasari, JM Bos, ET Kim, DJ Tester… - bioRxiv, 2024 - biorxiv.org
Background: Recently, we demonstrated transcriptional downregulation of hypertrophy
pathways in myectomy tissue derived from patients with obstructive hypertrophic …
pathways in myectomy tissue derived from patients with obstructive hypertrophic …
Unveiling miRNA Biomarkers for Hypertrophic Cardiomyopathy through Integrated Bioinformatics and Machine Learning Analysis
BE Yamasan, S Korkmaz - 2024 - researchsquare.com
This study explores microRNAs (miRNAs) as biomarkers for hypertrophic cardiomyopathy
(HCM), an inherited cardiac disease with clinical diversity and sudden death risk. Using …
(HCM), an inherited cardiac disease with clinical diversity and sudden death risk. Using …
Molecular mechanisms of thoracic aortic aneurysm in Marfan Syndrome
CX Dong - 2023 - ses.library.usyd.edu.au
Background: Marfan Syndrome (MFS) is a monogenic multisystem disorder resulting from
mutations in fibrillin-1, resulting in thoracic aortic aneurysm. Currently, effective treatments …
mutations in fibrillin-1, resulting in thoracic aortic aneurysm. Currently, effective treatments …
Учредители: Российская академия наук
МВ ПИСКЛОВА, ГЖ ОСЬМАК, ОО ФАВОРОВА - БИОХИМИЯ, 2022 - elibrary.ru
Гипертрофическая кардиомиопатия (ГКМП)-наследственная патология сердца,
обусловленная мутациями в генах саркомеров, которая сопровождается фиброзом …
обусловленная мутациями в генах саркомеров, которая сопровождается фиброзом …