Recombinant adeno-associated virus (AAV) is the leading vector for gene therapy in the
retina. As non-pathogenic, non-integrating, replication deficient vector, the recombinant virus …

More than 80 different adenovirus (AdV) types infect humans through the respiratory, ocular,
or gastrointestinal tracts. They cause acute clinical mani-festations or persist under humoral …

Abstract The Adeno-associated viruses (AAVs) are not associated with any diseases, and
their ability to package non-genomic DNA and to transduce different cell/tissue populations …

Understanding adeno-associated virus (AAV) trafficking is critical to advance our knowledge
of AAV biology and exploit novel aspects of vector development. Similar to the case for most …

Neurogenetic disorders typically affect cells throughout the brain. Adeno-associated virus
(AAV) vector-mediated transfer of a normal cDNA can correct the metabolic defects at the …

Early in infection, adenovirus travels to the nucleus as a naked capsid using the microtubule
motor cytoplasmic dynein. How the dynein complex is recruited to viral cargo remains …

Human immunodeficiency virus type 1 (HIV-1) infection depends on efficient
intracytoplasmic transport of the incoming viral core to the target cell nucleus. Evidence …

We have recently demonstrated the remarkable efficiency of self-complementary (sc) AAV9
vectors for central nervous system (CNS) gene transfer following intravenous delivery in …

The combination of biology and nanotechnology has led to a new generation of
nanodevices that make it possible to characterize the chemical, mechanical, and other …

Adenoviruses (AdVs) are widespread in vertebrates. They infect the respiratory and
gastrointestinal tracts, the eyes, heart, liver, and kidney, and are lethal to …