Parkinson's disease (PD) is a progressive neurodegenerative disorder caused mainly by
lack of dopamine in the brain. Dopamine is a neurotransmitter involved in movement …

Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis. In …

Alpha-synuclein is a presynaptic protein that forms abnormal cytoplasmic aggregates in
Lewy body disorders. Although nuclear alpha-synuclein localization has been described, its …

Parkinson's disease (PD) is the second most common neurodegenerative disorder, with a
documented significant increase in its prevalence in the past three decades. Both …

α-Synuclein is expressed at high levels at presynaptic terminals, but defining its role in the
regulation of neurotransmission under physiologically relevant conditions has proven …

In the pathophysiology of neurodegenerative disorders, the role of misfolded protein
deposition leading to neurodegeneration has been primarily discussed. In the last decade …

Abstract Alpha-synuclein (α-Syn), a small (14 kDa) protein associated with Parkinson's
disease, is abundant in human neural tissues. α-Syn plays an important role in maintaining …

Synucleinopathies are a group of neurodegenerative diseases with common pathological
lesions associated with the excessive accumulation and abnormal intracellular deposition of …

Long intergenic noncoding RNA‐p21 (lincRNA‐p21) has been reported to be increased in
Parkinson's disease (PD). However, the function and underlying mechanisms of lincRNA …

α‐Synuclein (αS) is a key molecule in the pathomechanism of Parkinson's disease. Most
studies on αS to date have focused on its function in the neuronal cytosol, but its action in …