Splice-switching oligonucleotides (SSOs) are short, synthetic, antisense, modified nucleic
acids that base-pair with a pre-mRNA and disrupt the normal splicing repertoire of the …

Here, we discuss three RNA-based therapeutic technologies exploiting various
oligonucleotides that bind to RNA by base pairing in a sequence-specific manner yet have …

Eosinophils can regulate local immune and inflammatory responses, and their accumulation
in the blood and tissue is associated with several inflammatory and infectious diseases …

Alternative splicing (AS) is a complex coordinated transcriptional regulatory mechanism. It
affects nearly 95% of all protein-coding genes and occurs in nearly all human organs …

Oligonucleotide chemistry has been developed greatly over the past three decades, with
many advances in increasing nuclease resistance, enhancing duplex stability and assisting …

Splicing of pre‐messenger RNA into mature messenger RNA is an essential step for the
expression of most genes in higher eukaryotes. Defects in this process typically affect …

Exon skipping is one of a number of ''steric blocking''applications of oligonucleotides (ONs)
and their analogues that in recent years have undergone a renaissance and which have led …

Alternative splicing has emerged as an important target for molecular therapies. Splice-
switching oligonucleotides (SSOs) modulate alternative splicing by hybridizing to pre-mRNA …

Alternative splicing enables a single pre-messenger RNA transcript to yield multiple protein
isoforms, making it a major contributor to the diversity of the proteome. While this process is …

Most protein-coding genes produce multiple protein isoforms; however, these isoforms are
commonly neglected in drug discovery. The expression of protein isoforms can be specific to …