In the last decade, it has become evident that RNA is frequently found in DNA. It is now well
established that single embedded ribonucleoside monophosphates (rNMPs) are primarily …

ABSTRACT DNA repair is essential for cell survival. In all domains of life, error-prone and
error-free repair pathways ensure maintenance of genome integrity under stress. Mutagenic …

The cellular imbalance between high concentrations of ribonucleotides (NTPs) and low
concentrations of deoxyribonucleotides (dNTPs), is challenging for DNA polymerases when …

Rev1 is a translesion DNA synthesis (TLS) polymerase involved in the bypass of adducted-
guanine bases and abasic sites during DNA replication. During damage bypass, Rev1 …

Translesion synthesis by translesion polymerases is a conserved mechanism of DNA
damage tolerance. In bacteria, DinB enzymes are the widely distributed promutagenic …

Research on Escherichia coli DNA replication paved the groundwork for many breakthrough
discoveries with important implications for our understanding of human molecular biology …

Telomere biology disorders (TBDs) are a spectrum of diseases that arise from mutations in
genes responsible for maintaining telomere integrity. Human telomerase reverse …

The X family is one of the eight families of DNA polymerases (dPols) and members of this
family are known to participate in the later stages of Base Excision Repair. Many prokaryotic …

Abstract Family D DNA polymerase (PolD) is the essential replicative DNA polymerase for
duplication of most archaeal genomes. PolD contains a unique two-barrel catalytic core …

Incorporation of ribonucleotides into DNA can severely diminish genome integrity. However,
how ribonucleotides instigate DNA damage is poorly understood. In DNA, they can promote …