One, no one, and one hundred thousand: the many forms of ribonucleotides in DNA
GM Nava, L Grasso, S Sertic, A Pellicioli… - International Journal of …, 2020 - mdpi.com
In the last decade, it has become evident that RNA is frequently found in DNA. It is now well
established that single embedded ribonucleoside monophosphates (rNMPs) are primarily …
established that single embedded ribonucleoside monophosphates (rNMPs) are primarily …
Visualizing mutagenic repair: novel insights into bacterial translesion synthesis
AM Joseph, A Badrinarayanan - FEMS Microbiology Reviews, 2020 - academic.oup.com
ABSTRACT DNA repair is essential for cell survival. In all domains of life, error-prone and
error-free repair pathways ensure maintenance of genome integrity under stress. Mutagenic …
error-free repair pathways ensure maintenance of genome integrity under stress. Mutagenic …
A sensor complements the steric gate when DNA polymerase ϵ discriminates ribonucleotides
V Parkash, Y Kulkarni, GO Bylund… - Nucleic Acids …, 2023 - academic.oup.com
The cellular imbalance between high concentrations of ribonucleotides (NTPs) and low
concentrations of deoxyribonucleotides (dNTPs), is challenging for DNA polymerases when …
concentrations of deoxyribonucleotides (dNTPs), is challenging for DNA polymerases when …
Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1
TM Weaver, TH Click, TH Khoang… - Nature …, 2022 - nature.com
Rev1 is a translesion DNA synthesis (TLS) polymerase involved in the bypass of adducted-
guanine bases and abasic sites during DNA replication. During damage bypass, Rev1 …
guanine bases and abasic sites during DNA replication. During damage bypass, Rev1 …
Roles for mycobacterial DinB2 in frameshift and substitution mutagenesis
Translesion synthesis by translesion polymerases is a conserved mechanism of DNA
damage tolerance. In bacteria, DinB enzymes are the widely distributed promutagenic …
damage tolerance. In bacteria, DinB enzymes are the widely distributed promutagenic …
Escherichia coli DNA replication: the old model organism still holds many surprises
K Łazowski, R Woodgate… - FEMS Microbiology …, 2024 - academic.oup.com
Research on Escherichia coli DNA replication paved the groundwork for many breakthrough
discoveries with important implications for our understanding of human molecular biology …
discoveries with important implications for our understanding of human molecular biology …
Altered Nucleotide Insertion Mechanisms of Disease-Associated TERT Variants
Telomere biology disorders (TBDs) are a spectrum of diseases that arise from mutations in
genes responsible for maintaining telomere integrity. Human telomerase reverse …
genes responsible for maintaining telomere integrity. Human telomerase reverse …
The PHP domain of PolX from Staphylococcus aureus aids high fidelity DNA synthesis through the removal of misincorporated deoxyribo-, ribo- and oxidized …
The X family is one of the eight families of DNA polymerases (dPols) and members of this
family are known to participate in the later stages of Base Excision Repair. Many prokaryotic …
family are known to participate in the later stages of Base Excision Repair. Many prokaryotic …
Novel ribonucleotide discrimination in the RNA polymerase-like two-barrel catalytic core of Family D DNA polymerases
KM Zatopek, E Alpaslan, TC Evans Jr… - Nucleic Acids …, 2020 - academic.oup.com
Abstract Family D DNA polymerase (PolD) is the essential replicative DNA polymerase for
duplication of most archaeal genomes. PolD contains a unique two-barrel catalytic core …
duplication of most archaeal genomes. PolD contains a unique two-barrel catalytic core …
Impact of 1, N6-ethenoadenosine, a damaged ribonucleotide in DNA, on translesion synthesis and repair
PP Ghodke, FP Guengerich - Journal of Biological Chemistry, 2020 - ASBMB
Incorporation of ribonucleotides into DNA can severely diminish genome integrity. However,
how ribonucleotides instigate DNA damage is poorly understood. In DNA, they can promote …
how ribonucleotides instigate DNA damage is poorly understood. In DNA, they can promote …