Plant‐derived vesicle‐like nanoparticles as promising biotherapeutic tools: Present and future

J Feng, Q Xiu, Y Huang, Z Troyer, B Li… - Advanced …, 2023 - Wiley Online Library
Extracellular vesicles (EVs) are heterogeneous, phospholipid bilayer‐enclosed biological
particles that regulate cell communication by molecular cargo delivery and surface …

Role of human milk bioactives on infants' gut and immune health

LE Carr, MD Virmani, F Rosa, D Munblit… - Frontiers in …, 2021 - frontiersin.org
Exclusive human milk feeding of the newborn is recommended during the first 6 months of
life to promote optimal health outcomes during early life and beyond. Human milk contains a …

Milk exosomes are bioavailable and distinct microRNA cargos have unique tissue distribution patterns

S Manca, B Upadhyaya, E Mutai, AT Desaulniers… - Scientific reports, 2018 - nature.com
Exosomes participate in cell-to-cell communication, facilitated by the transfer of RNAs,
proteins and lipids from donor to recipient cells. Exosomes and their RNA cargos do not …

Milk-derived exosomes for oral delivery of paclitaxel

AK Agrawal, F Aqil, J Jeyabalan, WA Spencer… - … , Biology and Medicine, 2017 - Elsevier
In this report milk-derived exosomes have been investigated for oral delivery of the
chemotherapeutic drug paclitaxel (PAC) as an alternative to conventional iv therapy for …

Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis

M Samuel, P Fonseka, R Sanwlani, L Gangoda… - Nature …, 2021 - nature.com
The concept that extracellular vesicles (EVs) from the diet can be absorbed by the intestinal
tract of the consuming organism, be bioavailable in various organs, and in-turn exert …

Exosome-derived microRNAs of human milk and their effects on infant health and development

BC Melnik, W Stremmel, R Weiskirchen, SM John… - Biomolecules, 2021 - mdpi.com
Multiple biologically active components of human milk support infant growth, health and
development. Milk provides a wide spectrum of mammary epithelial cell-derived …

Bovine milk-derived exosomes as a drug delivery vehicle for miRNA-based therapy

L del Pozo-Acebo, MC López de las Hazas… - International journal of …, 2021 - mdpi.com
MicroRNAs (miRNAs) are small non-coding RNAs with a known role as mediators of gene
expression in crucial biological processes, which converts them into high potential …

[HTML][HTML] MicroRNAs are absorbed in biologically meaningful amounts from nutritionally relevant doses of cow milk and affect gene expression in peripheral blood …

SR Baier, C Nguyen, F Xie, JR Wood, J Zempleni - The Journal of nutrition, 2014 - Elsevier
Background: MicroRNAs (miRNAs) regulate genes in animals and plants and can be
synthesized endogenously. In milk, miRNAs are encapsulated in exosomes, thereby …

Extracellular vesicles—connecting kingdoms

E Woith, G Fuhrmann, MF Melzig - International journal of molecular …, 2019 - mdpi.com
It is known that extracellular vesicles (EVs) are shed from cells of almost every type of cell or
organism, showing their ubiquity in all empires of life. EVs are defined as naturally released …

[HTML][HTML] The intestinal transport of bovine milk exosomes is mediated by endocytosis in human colon carcinoma Caco-2 cells and rat small intestinal IEC-6 cells

T Wolf, SR Baier, J Zempleni - The Journal of nutrition, 2015 - Elsevier
Background: MicroRNAs play essential roles in gene regulation. A substantial fraction of
microRNAs in tissues and body fluids is encapsulated in exosomes, thereby conferring …