Challenges and Future Perspectives in Modeling Neurodegenerative Diseases Using Organ‐on‐a‐Chip Technology
Neurodegenerative diseases (NDDs) affect more than 50 million people worldwide, posing
a significant global health challenge as well as a high socioeconomic burden. With aging …
a significant global health challenge as well as a high socioeconomic burden. With aging …
Towards in vitro models for reducing or replacing the use of animals in drug testing
Towards in vitro models for reducing or replacing the use of animals in drug testing | Nature
Biomedical Engineering Skip to main content Thank you for visiting nature.com. You are using …
Biomedical Engineering Skip to main content Thank you for visiting nature.com. You are using …
Bioengineering translational models of lymphoid tissues
YS Michaels, CF Buchanan, N Gjorevski… - Nature Reviews …, 2023 - nature.com
Bioengineered models of human tissues have the potential to revolutionize human health by
providing a translational platform to investigate disease mechanisms and develop new …
providing a translational platform to investigate disease mechanisms and develop new …
A generative adversarial network model alternative to animal studies for clinical pathology assessment
Animal studies are unavoidable in evaluating chemical and drug safety. Generative
Adversarial Networks (GANs) can generate synthetic animal data by learning from the …
Adversarial Networks (GANs) can generate synthetic animal data by learning from the …
Ready for regulatory use: NAMs and NGRA for chemical safety assurance
PL Carmichael, MT Baltazar, S Cable… - ALTEX-Alternatives to …, 2022 - altex.org
New approach methodologies (NAMs) that do not use experimental animals are, in certain
settings, entirely appropriate for assuring the safety of chemical ingredients, although …
settings, entirely appropriate for assuring the safety of chemical ingredients, although …
Microfluidic-based prostate cancer model for investigating the secretion of prostate-specific antigen and microRNAs in vitro
A Padmyastuti, MG Sarmiento, M Dib, J Ehrhardt… - Scientific Reports, 2023 - nature.com
The study of prostate cancer in vitro relies on established cell lines that lack important
physiological characteristics, such as proper polarization and expression of relevant …
physiological characteristics, such as proper polarization and expression of relevant …
Analysis of reproducibility and robustness of a renal proximal tubule microphysiological system OrganoPlate 3-lane 40 for in vitro studies of drug transport and toxicity
C Sakolish, HL Moyer, HHD Tsai, LC Ford… - Toxicological …, 2023 - academic.oup.com
Microphysiological systems are an emerging area of in vitro drug development, and their
independent evaluation is important for wide adoption and use. The primary goal of this …
independent evaluation is important for wide adoption and use. The primary goal of this …
Intestinal organ chips for disease modelling and personalized medicine
Alterations in intestinal structure, mechanics and physiology underlie acute and chronic
intestinal conditions, many of which are influenced by dysregulation of microbiome …
intestinal conditions, many of which are influenced by dysregulation of microbiome …
Reanalysis of Trichloroethylene and Tetrachloroethylene Metabolism to Glutathione Conjugates Using Human, Rat, and Mouse Liver in Vitro Models to Improve …
Background: Both trichloroethylene (TCE) and tetrachloroethylene (PCE) are high-priority
chemicals subject to numerous human health risk evaluations by a range of agencies …
chemicals subject to numerous human health risk evaluations by a range of agencies …
Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility
Cell culture technology has evolved, moving from single-cell and monolayer methods to 3D
models like reaggregates, spheroids, and organoids, improved with bioengineering like …
models like reaggregates, spheroids, and organoids, improved with bioengineering like …