Engineering nanosystems to overcome barriers to cancer diagnosis and treatment

SO Alhaj-Suliman, EI Wafa, AK Salem - Advanced drug delivery reviews, 2022 - Elsevier
Over the past two decades, multidisciplinary investigations into the development of
nanoparticles for medical applications have continually increased. However, nanoparticles …

Applications of nanovaccines for disease prevention in cattle

TW Maina, EA Grego, PM Boggiatto… - … in bioengineering and …, 2020 - frontiersin.org
Vaccines are one of the most important tools available to prevent and reduce the incidence
of infectious diseases in cattle. Despite their availability and widespread use to combat …

Cationic nanoparticles enhance T cell tumor infiltration and antitumor immune responses to a melanoma vaccine

R Smith, EI Wafa, SM Geary, K Ebeid… - Science …, 2022 - science.org
In clinical settings, cancer vaccines as monotherapies have displayed limited success
compared to other cancer immunotherapeutic treatments. Nanoscale formulations have the …

[HTML][HTML] Investigating the potential for genetic selection of dairy calf disease traits using management data

C Lynch, FS Schenkel, N van Staaveren, F Miglior… - Journal of dairy …, 2024 - Elsevier
Genetic selection could be a tool to help improve the health and welfare of calves; however,
to date, there is limited research on the genetics of calfhood diseases. This study aimed to …

Anti-Leptospira immunoglobulin profiling in mice reveals strain specific IgG and persistent IgM responses associated with virulence and renal colonization

F Vernel-Pauillac, GL Murray, B Adler… - PLoS Neglected …, 2021 - journals.plos.org
Leptospira interrogans is a pathogenic spirochete responsible for leptospirosis, a neglected,
zoonotic reemerging disease. Humans are sensitive hosts and may develop severe disease …

A review of UK-registered and candidate vaccines for bovine respiratory disease

JL Lemon, MJ McMenamy - Vaccines, 2021 - mdpi.com
Vaccination is widely regarded as a cornerstone in animal or herd health and infectious
disease management. Nineteen vaccines against the major pathogens implicated in bovine …

The role of asymptomatic cattle for leptospirosis dynamics in a herd with imperfect vaccination

AG Regassa, LL Obsu - Scientific Reports, 2024 - nature.com
Leptospirosis is an emerging zoonotic disease with high health and economic damage. In
this study, we developed a deterministic mathematical model that describes the dynamics of …

Trehalose diamide glycolipids augment antigen-specific antibody responses in a Mincle-dependent manner

AT Lynch, C Motozono, AJ Foster, K Kodar… - Bioorganic …, 2021 - Elsevier
Many studies have investigated how trehalose glycolipid structures can be modified to
improve their Macrophage inducible C-type lectin (Mincle)-mediated adjuvanticity. However …

[HTML][HTML] Cellular and humoral immune responsiveness to inactivated Leptospira interrogans in dogs vaccinated with a tetravalent Leptospira vaccine

A Novak, E Hindriks, A Hoek, C Veraart, EM Broens… - Vaccine, 2023 - Elsevier
Vaccination is commonly used to protect dogs against leptospirosis, however, memory
immune responses induced by canine Leptospira vaccines have not been studied. In the …

Bovine immune response to vaccination and infection with Leptospira borgpetersenii serovar Hardjo

JH Wilson-Welder, DP Alt, JE Nally, SC Olsen - Msphere, 2021 - Am Soc Microbiol
This study examined the humoral and cellular response of cattle vaccinated with two
commercial leptospiral vaccines, Leptavoid and Spirovac, and a novel bacterin vaccine …