Abstract Toll-like receptor 4 (TLR4), a member of the Toll-like receptor (TLR) family, is
involved in innate immunity and mediates inflammatory responses by recognizing …

The suite of currently used drugs can be divided into two categories–traditional 'small
molecule'drugs with typical molecular weights of< 500 Da but with oral bioavailability, and …

Highlights•Systematic design of experiments to optimize bioactive peptide
production.•Empirical and bioinformatics complementary approaches to bioactive peptide …

Controlled fabrication of nanosystems is essential in current science and technology. 1 One
of the most successful strategies for constructing such nanosystems is preparation of …

Since Hedin's characterization of trypsin and antitrypsin in 1906,(1) arguably the first
account of a regulatory protein–protein interaction (PPI), contemporary understanding of …

Introduction Chirality is immanent in nature, and chiral molecules can achieve their
pharmacological action through chiral matching with biomolecules and molecular …

Although the syntheses of novel and diverse peptides rely mainly on traditional coupling
using unnatural amino acids, postsynthetic modification of peptides could provide a …

Given the importance of nanoparticle surface composition in nanotoxicology, analytical tools
that can probe nanoparticle surfaces in aqueous media are crucial but remain limited …

Flexible peptides that fold upon binding to another protein molecule mediate a large number
of regulatory interactions in the living cell and may provide highly specific recognition …

Highlights•PPIs that are dominated by a continuous epitope are amenable for inhibition.•A
significant share of PPIs contains such 'hot segments'.•Peptide-based inhibitors are obvious …