Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine
Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …
now can generate most cells of the human body in the laboratory. PSC-derived …
Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection
HE Bøtker, D Hausenloy, I Andreadou… - Basic research in …, 2018 - Springer
The potential for ischemic preconditioning to reduce infarct size was first recognized more
than 30 years ago [180]. Despite extension of the concept to ischemic postcondition‑ing …
than 30 years ago [180]. Despite extension of the concept to ischemic postcondition‑ing …
Mitochondria bound to lipid droplets have unique bioenergetics, composition, and dynamics that support lipid droplet expansion
Mitochondria associate with lipid droplets (LDs) in fat-oxidizing tissues, but the functional
role of these peridroplet mitochondria (PDM) is unknown. Microscopic observation of …
role of these peridroplet mitochondria (PDM) is unknown. Microscopic observation of …
Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue
Age is the most important risk factor for most diseases. Mitochondria play a central role in
bioenergetics and metabolism. In addition, several lines of evidence indicate the impact of …
bioenergetics and metabolism. In addition, several lines of evidence indicate the impact of …
Mitochondrial quality control mechanisms as molecular targets in cardiac ageing
Cardiovascular disease is the leading cause of morbidity and mortality worldwide.
Advancing age is a major risk factor for developing cardiovascular disease because of the …
Advancing age is a major risk factor for developing cardiovascular disease because of the …
Mitochondrial dysfunction and myocardial ischemia-reperfusion: implications for novel therapies
EJ Lesnefsky, Q Chen, B Tandler… - Annual review of …, 2017 - annualreviews.org
Mitochondria have emerged as key participants in and regulators of myocardial injury during
ischemia and reperfusion. This review examines the sites of damage to cardiac …
ischemia and reperfusion. This review examines the sites of damage to cardiac …
The role of oxidative stress in myocardial ischemia and reperfusion injury and remodeling: revisited
GA Kurian, R Rajagopal, S Vedantham… - … medicine and cellular …, 2016 - Wiley Online Library
Oxidative and reductive stress are dual dynamic phases experienced by the cells
undergoing adaptation towards endogenous or exogenous noxious stimulus. The former …
undergoing adaptation towards endogenous or exogenous noxious stimulus. The former …
High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle
D Pesta, E Gnaiger - Mitochondrial bioenergetics: methods and protocols, 2012 - Springer
Protocols for high-resolution respirometry (HRR) of intact cells, permeabilized cells, and
permeabilized muscle fibers offer sensitive diagnostic tests of integrated mitochondrial …
permeabilized muscle fibers offer sensitive diagnostic tests of integrated mitochondrial …
Mitochondrial metabolism in aging heart
EJ Lesnefsky, Q Chen, CL Hoppel - Circulation research, 2016 - Am Heart Assoc
Altered mitochondrial metabolism is the underlying basis for the increased sensitivity in the
aged heart to stress. The aged heart exhibits impaired metabolic flexibility, with a decreased …
aged heart to stress. The aged heart exhibits impaired metabolic flexibility, with a decreased …
High-resolution FluoRespirometry and OXPHOS protocols for human cells, permeabilized fibers from small biopsies of muscle, and isolated mitochondria
C Doerrier, LF Garcia-Souza, G Krumschnabel… - … : Methods and Protocols, 2018 - Springer
Abstract Protocols for High-Resolution FluoRespirometry of intact cells, permeabilized cells,
permeabilized muscle fibers, isolated mitochondria, and tissue homogenates offer sensitive …
permeabilized muscle fibers, isolated mitochondria, and tissue homogenates offer sensitive …