Toxic influence of organophosphate, carbamate, and organochlorine pesticides on cellular metabolism of lipids, proteins, and carbohydrates: a systematic review
S Karami-Mohajeri, M Abdollahi - Human & experimental …, 2011 - journals.sagepub.com
Pesticides, including organophosphate (OP), organochlorine (OC), and carbamate (CB)
compounds, are widely used in agricultural and indoor purposes. OP and CB act as acetyl …
compounds, are widely used in agricultural and indoor purposes. OP and CB act as acetyl …
The three-gene paraoxonase family: physiologic roles, actions and regulation
LP Précourt, D Amre, MC Denis, JC Lavoie, E Delvin… - Atherosclerosis, 2011 - Elsevier
The paraoxonase (PON) gene family is composed of three members (PON1, PON2, PON3)
that share considerable structural homology and are located adjacently on chromosome 7 in …
that share considerable structural homology and are located adjacently on chromosome 7 in …
Effects of metformin on markers of oxidative stress and antioxidant reserve in patients with newly diagnosed type 2 diabetes: a randomized clinical trial
BACKGROUND & AIMS: Given the long term benefits observed with metformin use in
diabetes patients, a role in modulating oxidative stress is imputable. Effects of metformin on …
diabetes patients, a role in modulating oxidative stress is imputable. Effects of metformin on …
Catalytic mechanisms for phosphotriesterases
AN Bigley, FM Raushel - Biochimica et Biophysica Acta (BBA)-Proteins and …, 2013 - Elsevier
Phosphotriesters are one class of highly toxic synthetic compounds known as
organophosphates. Wide spread usage of organophosphates as insecticides as well as …
organophosphates. Wide spread usage of organophosphates as insecticides as well as …
Importance of paraoxonase 1 (PON1) as an antioxidant and antiatherogenic enzyme in the cardiovascular complications of type 2 diabetes: Genotypic and phenotypic …
Y Shokri, A Variji, M Nosrati, A Khonakdar-Tarsi… - Diabetes research and …, 2020 - Elsevier
Oxidant–antioxidant imbalance is involved in the etiology of different diseases, including
cardiovascular diseases (CVDs), liver disorders, kidney diseases, cancers and diabetes …
cardiovascular diseases (CVDs), liver disorders, kidney diseases, cancers and diabetes …
Serum paraoxonase 1 (PON1) measurement: an update
JJ Ceron, F Tecles, A Tvarijonaviciute - BMC veterinary research, 2014 - Springer
Abstract Paraoxonase 1 (PON1) is a widely studied enzyme based on its protective role
against poisoning by organophosphate (OP) metabolites of specific OP insecticides and in …
against poisoning by organophosphate (OP) metabolites of specific OP insecticides and in …
Paraoxonase 1 (PON1) as a genetic determinant of susceptibility to organophosphate toxicity
LG Costa, G Giordano, TB Cole, J Marsillach… - Toxicology, 2013 - Elsevier
Paraoxonase (PON1) is an A-esterase capable of hydrolyzing the active metabolites (oxons)
of a number of organophosphorus (OP) insecticides such as parathion, diazinon and …
of a number of organophosphorus (OP) insecticides such as parathion, diazinon and …
One enzyme, two functions: PON2 prevents mitochondrial superoxide formation and apoptosis independent from its lactonase activity
S Altenhöfer, I Witte, JF Teiber, P Wilgenbus… - Journal of Biological …, 2010 - ASBMB
The human enzyme paraoxonase-2 (PON2) has two functions, an enzymatic lactonase
activity and the reduction of intracellular oxidative stress. As a lactonase, it dominantly …
activity and the reduction of intracellular oxidative stress. As a lactonase, it dominantly …
Pharmacological and dietary modulators of paraoxonase 1 (PON1) activity and expression: the hunt goes on
LG Costa, G Giordano, CE Furlong - Biochemical pharmacology, 2011 - Elsevier
Paraoxonase 1 (PON1) is a high density lipoprotein (HDL)-associated enzyme displaying
esterase and lactonase activity. PON1 hydrolyzes several organophosphorus (OP) …
esterase and lactonase activity. PON1 hydrolyzes several organophosphorus (OP) …
HDL proteome and Alzheimer's disease: evidence of a link
Several lines of epidemiological evidence link increased levels of high-density lipoprotein-
cholesterol (HDL-C) with lower risk of Alzheimer's disease (AD). This observed relationship …
cholesterol (HDL-C) with lower risk of Alzheimer's disease (AD). This observed relationship …