Metabolic coordination of T cell quiescence and activation
NM Chapman, MR Boothby, H Chi - Nature reviews immunology, 2020 - nature.com
Naive T cells are actively maintained in a quiescent state that promotes their survival and
persistence. On antigen stimulation, T cells exit quiescence to initiate clonal expansion and …
persistence. On antigen stimulation, T cells exit quiescence to initiate clonal expansion and …
Interleukin-7 biology and its effects on immune cells: mediator of generation, differentiation, survival, and homeostasis
D Chen, TX Tang, H Deng, XP Yang… - Frontiers in …, 2021 - frontiersin.org
Interleukin-7 (IL-7), a molecule known for its growth-promoting effects on progenitors of B
cells, remains one of the most extensively studied cytokines. It plays a vital role in health …
cells, remains one of the most extensively studied cytokines. It plays a vital role in health …
Rethinking peripheral T cell tolerance: checkpoints across a T cell's journey
MA ElTanbouly, RJ Noelle - Nature Reviews Immunology, 2021 - nature.com
Following their exit from the thymus, T cells are endowed with potent effector functions but
must spare host tissue from harm. The fate of these cells is dictated by a series of …
must spare host tissue from harm. The fate of these cells is dictated by a series of …
Flip the coin: IL-7 and IL-7R in health and disease
The cytokine IL-7 and its receptor, IL-7R, are critical for T cell and, in the mouse, B cell
development, as well as differentiation and survival of naive T cells, and generation and …
development, as well as differentiation and survival of naive T cells, and generation and …
Metabolic profiling using stable isotope tracing reveals distinct patterns of glucose utilization by physiologically activated CD8+ T cells
Naive CD8+ T cells differentiating into effector T cells increase glucose uptake and shift from
quiescent to anabolic metabolism. Although much is known about the metabolism of …
quiescent to anabolic metabolism. Although much is known about the metabolism of …
IL7 genetic variation and toxicity to immune checkpoint blockade in patients with melanoma
CA Taylor, RA Watson, O Tong, W Ye, I Nassiri… - Nature Medicine, 2022 - nature.com
Abstract Treatment with immune checkpoint blockade (ICB) frequently triggers immune-
related adverse events (irAEs), causing considerable morbidity. In 214 patients receiving …
related adverse events (irAEs), causing considerable morbidity. In 214 patients receiving …
T cell metabolism drives immunity
Lymphocytes must adapt to a wide array of environmental stressors as part of their normal
development, during which they undergo a dramatic metabolic remodeling process …
development, during which they undergo a dramatic metabolic remodeling process …
Etomoxir actions on regulatory and memory T cells are independent of Cpt1a-mediated fatty acid oxidation
T cell subsets including effector (T eff), regulatory (T reg), and memory (T mem) cells are
characterized by distinct metabolic profiles that influence their differentiation and function …
characterized by distinct metabolic profiles that influence their differentiation and function …
The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function
AN Macintyre, VA Gerriets, AG Nichols, RD Michalek… - Cell metabolism, 2014 - cell.com
CD4 T cell activation leads to proliferation and differentiation into effector (Teff) or regulatory
(Treg) cells that mediate or control immunity. While each subset prefers distinct glycolytic or …
(Treg) cells that mediate or control immunity. While each subset prefers distinct glycolytic or …