In recent years, hydrogel-based three-dimensional tumor models have become increasingly
mainstream for cancer research. Hydrogels enable recapitulation of biochemical and …

One of the major challenges in the treatment of cancer are differential responses of patients
to existing standard of care anti-cancer drugs. These differential responses may, in part, be …

Wnt/β‐catenin signaling is frequently activated in advanced prostate cancer and contributes
to therapy resistance and metastasis. However, activating mutations in the Wnt/β‐catenin …

Basement membrane extracts (BME) derived from Engelbreth–Holm–Swarm (EHS) mouse
sarcomas such as Matrigel® remain the gold standard extracellular matrix (ECM) for three …

Simple Summary Colorectal cancer (CRC) is one of the most frequently diagnosed and
lethal malignancies. The majority of CRC patients experience disease relapse after the …

Cancer stem cells (CSCs), a rare cell population in tumors, are resistant to conventional
chemotherapy and thus responsible for tumor recurrence. To screen for active compounds …

Cancer stem cells (CSCs), which act as an important bridge between cancer formation and
embryonic development, represent a small population associated with tumor initiation, drug …

Structural maintenance of chromosomes protein 2 (SMC2) is a central component of the
condensin complex involved in DNA supercoiling, an essential process for embryonic stem …

Cancer stem cells (CSCs) are a rare tumor subpopulation with high differentiation,
proliferative and tumorigenic potential compared to the remaining tumor population. CSCs …

Aims Chemoresistance remains a persistent challenge in advanced prostate cancer therapy.
Probenecid reportedly inhibits multiple drug-efflux transporters; hence, it can be employed …