The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and
malignant cells and can provide long-term protective immunity. In the response to infection …

Metabolic pathways and redox reactions are at the core of life. In the past decade (s),
numerous discoveries have shed light on how metabolic pathways determine the cellular …

T cells play a determining role in the immunomodulation and prognostic evaluation of
cancer treatments relying on immune activation. While specific biomarkers determine the …

Reactive oxygen species (ROS) are a group of short-lived highly reactive molecules formed
intracellularly from molecular oxygen. ROS can alter biochemical, transcriptional, and …

The cytosolic selenoprotein thioredoxin reductase 1 (TrxR1, TXNRD1), and to some extent
mitochondrial TrxR2 (TXNRD2), can be inhibited by a wide range of electrophilic …

Human thioredoxin reductase (TrxR) is a selenoprotein with a central role in cellular redox
homeostasis, utilizing a highly reactive and solvent-exposed selenocysteine (Sec) residue in …

To improve the clinical outcome of adoptive NK cell therapy in patients with solid tumors, NK
cells need to persist within the tumor microenvironment (TME) in which the abundance of …

Significance: Thioredoxin (Trx) is a powerful antioxidant that reduces protein disulfides to
maintain redox stability in cells and is involved in regulating multiple redox-dependent …

The incidence of cancer is increasing year by year. Cancer has become one of the health
threats of modern people. Simply relying on the surgery, chemotherapy or radiotherapy, not …