In sexually reproducing organisms, the genetic information is transmitted from one
generation to the next via the merger of male and female gametes. Gamete fusion is a two …

Gamete fusion is the climax of fertilization in all sexually reproductive organisms, from
unicellular fungi to humans. Similarly to other cell-cell fusion events, gamete fusion is …

Sexual reproduction involves the fusion of two gametes of opposite sex. Although the sperm-
expressed fusogen HAPLESS 2 (HAP2) or GENERATIVE CELL SPECIFIC 1 (GCS1) plays a …

The fusion of mononucleated myoblasts produces multinucleated muscle fibers leading to
the formation of skeletal muscle. Myomaker, a skeletal muscle-specific membrane protein, is …

The process of sperm-egg fusion is critical for successful fertilization, yet the underlying
mechanisms that regulate these steps have remained unclear in vertebrates. Here, we show …

Viral entry and fertilization are distinct biological processes that share a common
mechanism: membrane fusion. In viral entry, enveloped viruses attach to the host cell …

Most, if not all the cellular requirements for fertilization and sexual reproduction arose early
in evolution and are retained in extant lineages of single-celled organisms including a …

Here, we study the gamete fusogen HAP2 from Cyanidioschyzon merolae (Cyani), an
extremophile red algae that grows at acidic pH at 45° C. HAP2 has a trimeric postfusion …

In the sexual reproduction of flowering plants, two independent fertilization events occur
almost simultaneously: two identical sperm cells fuse with either the egg cell or the central …

During sexual reproduction in the unicellular green alga Chlamydomonas, gametes
undergo the conserved cellular events that define fertilization across the tree of life. After …