Exploiting advanced hydrogel technologies to address key challenges in regenerative medicine

DA Foyt, MDA Norman, TTL Yu… - Advanced healthcare …, 2018 - Wiley Online Library
Regenerative medicine aims to tackle a panoply of challenges from repairing focal damage
to articular cartilage to preventing pathological tissue remodeling after myocardial infarction …

Impaired skeletal muscle regeneration in diabetes: From cellular and molecular mechanisms to novel treatments

E Espino-Gonzalez, E Dalbram, R Mounier, J Gondin… - Cell Metabolism, 2024 - cell.com
Diabetes represents a major public health concern with a considerable impact on human life
and healthcare expenditures. It is now well established that diabetes is characterized by a …

Ionic silicon protects oxidative damage and promotes skeletal muscle cell regeneration

K Awad, N Ahuja, M Fiedler, S Peper, Z Wang… - International journal of …, 2021 - mdpi.com
Volumetric muscle loss injuries overwhelm the endogenous regenerative capacity of
skeletal muscle, and the associated oxidative damage can delay regeneration and prolong …

Injectable alginate hydrogel for enhanced spatiotemporal control of lentivector delivery in murine skeletal muscle

RS Stilhano, JL Madrigal, K Wong, PA Williams… - Journal of Controlled …, 2016 - Elsevier
Hydrogels are an especially appealing class of biomaterials for gene delivery vehicles as
they can be introduced into the body with minimally invasive procedures and are often …

Cellular biomechanics in skeletal muscle regeneration

EW Li, OC McKee-Muir, PM Gilbert - Current topics in developmental …, 2018 - Elsevier
Satellite cells, adult stem cells in skeletal muscle tissue, reside within a mechanically
dynamic three-dimensional microenvironment. With each contraction–relaxation cycle, a …

Application of bone marrow–derived mesenchymal stem cells for muscle healing after contusion injury in mice

CH Chiu, TH Chang, SS Chang… - … American journal of …, 2020 - journals.sagepub.com
Background: Skeletal muscle injuries are very common in sports medicine. Conventional
therapies have limited clinical efficacy. New treatment methods should be developed to …

Bioactive glass and silica particles for skeletal and cardiac muscle tissue regeneration

D Ege, HH Lu, AR Boccaccini - Tissue Engineering Part B: Reviews, 2024 - liebertpub.com
When skeletal and cardiac tissues are damaged, surgical approaches are not always
successful and tissue regeneration approaches are investigated. Reports in the literature …

Proceedings of the signature series symposium “cellular therapies for orthopaedics and musculoskeletal disease proven and unproven therapies—promise, facts and …

NS Piuzzi, M Dominici, M Long, C Pascual-Garrido… - Cytotherapy, 2018 - Elsevier
Abstract The Signature Series Symposium “Cellular Therapies for Orthopaedics and
Musculoskeletal Disease Proven and Unproven Therapies—Promise, Facts and Fantasy” …

Injectable and Dynamically‐Crosslinked Zwitterionic Hydrogels for Anti‐Fouling and Tissue Regeneration Applications

Z Pan, J Dorogin, A Lofts, G Randhawa… - Advanced …, 2024 - Wiley Online Library
We report a zwitterionic injectable and degradable hydrogel based on hydrazide and
aldehyde‐functionalized [2‐(methacryloyloxy) ethyl] dimethyl‐(3‐sulfopropyl) ammonium …

Biomaterial-guided gene delivery for musculoskeletal tissue repair

JL Madrigal, R Stilhano, EA Silva - Tissue Engineering Part B …, 2017 - liebertpub.com
Gene therapy is a promising strategy for musculoskeletal tissue repair and regeneration
where local and sustained expression of proteins and/or therapeutic nucleic acids can be …