Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …

Autophagy and the ubiquitin–proteasome system (UPS) are the two major intracellular
quality control and recycling mechanisms that are responsible for cellular homeostasis in …

Ubiquitination is a post-translational modification (PTM) that is essential for balancing
numerous physiological processes. To enable delineation of protein ubiquitination at a site …

Autophagy and the ubiquitin–proteasome system are the two major quality control pathways
responsible for cellular homeostasis. As such, they provide protection against age …

Autophagosome biogenesis involves de novo formation of a membrane that elongates to
sequester cytoplasmic cargo and closes to form a double-membrane vesicle (an …

Autophagy is a lysosome-dependent cellular degradation program that responds to a variety
of environmental and cellular stresses. It is an evolutionarily well-conserved and essential …

Ubiquitylation is an essential posttranslational modification that controls cell division,
differentiation, and survival in all eukaryotes. By combining multiple E3 ligases (writers) …

Autophagy is a major degradation pathway that utilizes lysosome hydrolases to degrade
cellular constituents and is often induced under cellular stress conditions to restore cell …

Ubiquitination is a widespread post-translational modification that controls multiple steps in
autophagy, a major lysosome-mediated intracellular degradation pathway. A variety of …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …