Scaffold-free cell-based tissue engineering therapies: advances, shortfalls and forecast
Cell-based scaffold-free therapies seek to develop in vitro organotypic three-dimensional
(3D) tissue-like surrogates, capitalising upon the inherent capacity of cells to create tissues …
(3D) tissue-like surrogates, capitalising upon the inherent capacity of cells to create tissues …
The physical microenvironment of hematopoietic stem cells and its emerging roles in engineering applications
P Zhang, C Zhang, J Li, J Han, X Liu… - Stem Cell Research & …, 2019 - Springer
Stem cells are considered the fundamental underpinnings of tissue biology. The stem cell
microenvironment provides factors and elements that play significant roles in controlling the …
microenvironment provides factors and elements that play significant roles in controlling the …
The role of bioreactors in tissue engineering
I Martin, D Wendt, M Heberer - TRENDS in Biotechnology, 2004 - cell.com
Ex vivo engineering of living tissues is a rapidly developing area with the potential to impact
significantly on a wide-range of biomedical applications. Major obstacles to the generation …
significantly on a wide-range of biomedical applications. Major obstacles to the generation …
Electrical and mechanical stimulation of cardiac cells and tissue constructs
The field of cardiac tissue engineering has made significant strides over the last few
decades, highlighted by the development of human cell derived constructs that have shown …
decades, highlighted by the development of human cell derived constructs that have shown …
Directed 3D cell alignment and elongation in microengineered hydrogels
Organized cellular alignment is critical to controlling tissue microarchitecture and biological
function. Although a multitude of techniques have been described to control cellular …
function. Although a multitude of techniques have been described to control cellular …
Accordion-like honeycombs for tissue engineering of cardiac anisotropy
GC Engelmayr Jr, M Cheng, CJ Bettinger… - Nature materials, 2008 - nature.com
Tissue-engineered grafts may be useful in myocardial repair; however, previous scaffolds
have been structurally incompatible with recapitulating cardiac anisotropy. Here, we use …
have been structurally incompatible with recapitulating cardiac anisotropy. Here, we use …
Patterning human stem cells and endothelial cells with laser printing for cardiac regeneration
R Gaebel, N Ma, J Liu, J Guan, L Koch, C Klopsch… - Biomaterials, 2011 - Elsevier
Recent study showed that mesenchymal stem cells (MSC) could inhibit apoptosis of
endothelial cells in hypoxic condition, increase their survival, and stimulate the …
endothelial cells in hypoxic condition, increase their survival, and stimulate the …
PGS: Gelatin nanofibrous scaffolds with tunable mechanical and structural properties for engineering cardiac tissues
A significant challenge in cardiac tissue engineering is the development of biomimetic grafts
that can potentially promote myocardial repair and regeneration. A number of approaches …
that can potentially promote myocardial repair and regeneration. A number of approaches …
Maturing human pluripotent stem cell-derived cardiomyocytes in human engineered cardiac tissues
NT Feric, M Radisic - Advanced drug delivery reviews, 2016 - Elsevier
Engineering functional human cardiac tissue that mimics the native adult morphological and
functional phenotype has been a long held objective. In the last 5 years, the field of cardiac …
functional phenotype has been a long held objective. In the last 5 years, the field of cardiac …
The effect of cyclic stretch on maturation and 3D tissue formation of human embryonic stem cell-derived cardiomyocytes
A Mihic, J Li, Y Miyagi, M Gagliardi, SH Li, J Zu… - Biomaterials, 2014 - Elsevier
The goal of cardiac tissue engineering is to restore function to the damaged myocardium
with regenerative constructs. Human embryonic stem cell–derived cardiomyocytes (hESC …
with regenerative constructs. Human embryonic stem cell–derived cardiomyocytes (hESC …