Systemic lupus erythematosus (SLE) is a chronic autoimmune disease affecting multiple
organs. A complex interaction of genetics, environment, and hormones leads to immune …

As the world navigates the coronavirus disease 2019 (COVID-19) pandemic, there is a
growing need to assess its impact in patients with autoimmune rheumatic diseases, such as …

The majority of patients with systemic lupus erythematosus (SLE) have high expression of
type I IFN-stimulated genes. Mitochondrial abnormalities have also been reported, but the …

Patients with systemic lupus erythematosus (SLE) suffer frequent infections that account for
significant morbidity and mortality. T cell cytotoxic responses are decreased in patients with …

Highlights•T cell transcriptomes can stratify patients.•T H17, Double-Negative and γδT cells
contribute to lupus nephritis.•T cell support autoantibody production in lymphoid and non …

Deficiency of C1q, the initiator of the complement classical pathway, is associated with the
development of systemic lupus erythematosus (SLE). Explaining this association in terms of …

Abstract Purpose of Review Systemic lupus erythematosus is a complex disease with broad
spectrum of clinical manifestations. In addition to abnormal B cell responsive leading to …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that predominately
affects women. It is characterised by a broad spectrum of clinical manifestations, however, its …

Background Because of the shortage of ideal cell surface antigens, the development of T-
cell receptor (TCR)-engineered T cells (TCR-T) that target intracellular antigens such as NY …

Proteins in the signaling lymphocytic activating molecule (SLAM) family play crucial roles in
regulating the immune system. CD244 (SLAMF4) is a protein in this family, and is also a …