Pathophysiology of L-dopa-induced motor and non-motor complications in Parkinson's disease
Involuntary movements, or dyskinesia, represent a debilitating complication of levodopa (L-
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …
dopa) therapy for Parkinson's disease (PD). L-dopa-induced dyskinesia (LID) are ultimately …
Compensatory mechanisms in Parkinson's disease: circuits adaptations and role in disease modification
The motor features of Parkinson's disease (PD) are well known to manifest only when striatal
dopaminergic deficit reaches 60–70%. Thus, PD has a long pre-symptomatic and pre-motor …
dopaminergic deficit reaches 60–70%. Thus, PD has a long pre-symptomatic and pre-motor …
[HTML][HTML] Cell type-specific plasticity of striatal projection neurons in parkinsonism and L-DOPA-induced dyskinesia
T Fieblinger, SM Graves, LE Sebel, C Alcacer… - Nature …, 2014 - nature.com
The striatum is widely viewed as the fulcrum of pathophysiology in Parkinson's disease (PD)
and L-DOPA-induced dyskinesia (LID). In these disease states, the balance in activity of …
and L-DOPA-induced dyskinesia (LID). In these disease states, the balance in activity of …
[HTML][HTML] Striatal Neurons Expressing D1 and D2 Receptors are Morphologically Distinct and Differently Affected by Dopamine Denervation in Mice
The loss of nigrostriatal dopamine neurons in Parkinson's disease induces a reduction in the
number of dendritic spines on medium spiny neurons (MSNs) of the striatum expressing D1 …
number of dendritic spines on medium spiny neurons (MSNs) of the striatum expressing D1 …
[HTML][HTML] Presynaptic Mechanisms of l-DOPA-Induced Dyskinesia: The Findings, the Debate, and the Therapeutic Implications
MA Cenci - Frontiers in neurology, 2014 - frontiersin.org
The dopamine (DA) precursor l-DOPA has been the most effective treatment for Parkinson's
disease (PD) for over 40 years. However, the response to this treatment changes with …
disease (PD) for over 40 years. However, the response to this treatment changes with …
[HTML][HTML] The thalamostriatal system in normal and diseased states
Because of our limited knowledge of the functional role of the thalamostriatal system, this
massive network is often ignored in models of the pathophysiology of brain disorders of …
massive network is often ignored in models of the pathophysiology of brain disorders of …
[HTML][HTML] Striatal glutamatergic hyperactivity in Parkinson's disease
F Campanelli, G Natale, G Marino, V Ghiglieri… - Neurobiology of …, 2022 - Elsevier
Glutamatergic hyperactivity in the nucleus striatum, the main basal ganglia input, has been
involved in the progression of Parkinson's disease (PD) and the onset of L-Dopa-induced …
involved in the progression of Parkinson's disease (PD) and the onset of L-Dopa-induced …
Dopaminergic modulation of striatal networks in health and Parkinson's disease
DJ Surmeier, SM Graves, W Shen - Current opinion in neurobiology, 2014 - Elsevier
Highlights•Spiny projection neurons do not just differ in their expression of dopamine
receptors.•The signaling mechanisms controlling synaptic plasticity are diverse.•Cholinergic …
receptors.•The signaling mechanisms controlling synaptic plasticity are diverse.•Cholinergic …
[HTML][HTML] Distributed dopaminergic signaling in the basal ganglia and its relationship to motor disability in Parkinson's disease
The degeneration of mesencephalic dopaminergic neurons that innervate the basal ganglia
is responsible for the cardinal motor symptoms of Parkinson's disease (PD). It has been …
is responsible for the cardinal motor symptoms of Parkinson's disease (PD). It has been …
L-DOPA oppositely regulates synaptic strength and spine morphology in D1 and D2 striatal projection neurons in dyskinesia
Dopamine depletion in Parkinson's disease (PD) produces dendritic spine loss in striatal
medium spiny neurons (MSNs) and increases their excitability. However, the synaptic …
medium spiny neurons (MSNs) and increases their excitability. However, the synaptic …