Over 600 million years ago, animals evolved from a unicellular or colonial organism whose
cell (s) captured bacteria with a collar complex, a flagellum surrounded by a microvillar …

Beyond fuelling cellular activities with building blocks and energy, metabolism also
integrates environmental conditions into intracellular signals. The underlying regulatory …

To exist in a wide range of environmental niches, bacteria must sense and respond to a
variety of external signals. A primary means by which this occurs is through two-component …

The phosphoenolpyruvate (PEP): carbohydrate phosphotransferase system (PTS) is found
only in bacteria, where it catalyzes the transport and phosphorylation of numerous …

For more than a decade, numerous studies have suggested that the c-Myc oncogenic
protein is likely to broadly influence the composition of the transcriptome. However, the …

Bacteria use their genetic material with great effectiveness to make the right products in the
correct amounts at the appropriate time. Studying bacterial transcription initiation in …

We have developed a general profile for the proteins of the TetR family of repressors. The
stretch that best defines the profile of this family is made up of 47 amino acid residues that …

The regulatory interactions between transcription factors and their target genes can be
conceptualised as a directed graph. At a global level, these regulatory networks display a …

Although antibiotics have long been known to have multiple effects on bacterial cells at low
concentrations, it is only with the advent of genome transcription analyses that these …

Network inference, which is the reconstruction of biological networks from high-throughput
data, can provide valuable information about the regulation of gene expression in cells …