Nickel is an essential nutrient for selected microorganisms where it participates in a variety
of cellular processes. Many microbes are capable of sensing cellular nickel ion …

The Tat (t win‐a rginine t ranslocation) system is a bacterial protein export pathway with the
remarkable ability to transport folded proteins across the cytoplasmic membrane …

Nickel is an essential catalytic cofactor of enzymes found in eubacteria, archaebacteria,
fungi, and plants. 1-6 These enzymes catalyze a diverse array of reactions that include both …

Bacterial periplasmic nickel-containing hydrogenases are composed of a small subunit
containing a twin-arginine signal sequence and a large subunit devoid of an export signal …

Nascent polypeptides emerging from the ribosome are assisted by a pool of molecular
chaperones and targeting factors, which enable them to efficiently partition as cytosolic …

The [NiFe] centers at the active sites of the Escherichia coli hydrogenase enzymes are
assembled by a team of accessory proteins that includes the products of the hyp genes. To …

Nickel enzymes are a relatively new class of metalloenzymes. The seven known nickel
enzymes are urease, hydrogenase, CO-dehydrogenase, methyl-coenzyme M reductase, Ni …

The Tat (twin-arginine transport) pathway is a protein-targeting system dedicated to the
transmembrane translocation of fully folded proteins. This system is highly prevalent in the …

Colicin V (ColV) is a peptide antibiotic that kills sensitive cells by disrupting their membrane
potential once it gains access to the inner membrane from the periplasmic face. Recently …

The discovery of penicillin by Alexander Fleming marked a new era for modern medicine,
allowing not only the treatment of infectious diseases, but also the safe performance of life …