About 50 years ago, pioneering work initiated by Silvio Weidmann and others applied the
Hodgkin-Huxley formalism of membrane excitation to interpret the cardiac electrical activity …

For almost half a century it has been thought that the initiation of each heartbeat is driven by
surface membrane voltage-gated ion channels (M clocks) within sinoatrial nodal cells. It has …

Calcium dynamics is not only responsible for maintaining the framework and functions of the
cell but also plays a role in the dynamics of other biochemical systems in the cell …

Abstract Calcium (C a 2+), inositol trisphosphate (IP 3), and nitric oxide (NO) signaling are
essential to maintain the structural integrity and physiological activity of fibroblast cells. The …

The vital participation of C a 2+ in human organ functions such as muscular contractions,
heartbeat, brain functionality, skeletal activity, etc, motivated the scientists to thoroughly …

Fibroblast cells are involved in the mechanism of growth and repair of tissue in human
organs. Calcium (Ca2+) signaling is essentially required to maintain the microstructure and …

Early afterdepolarization (EAD) is known to cause lethal ventricular arrhythmias in long QT
syndrome (LQTS). In this study, dynamical mechanisms of EAD formation in human …

To elucidate the roles of sarcoplasmic reticulum (SR) Ca2+ cycling and Na+/Ca2+
exchanger (NCX) in sinoatrial node (SAN) pacemaking, we have applied stability and …

We show that a class of arbitrary, autonomous kinetic equations in two variables describing
chemical and biochemical oscillations can be reduced to the form of a Liénard oscillator …

PT-2385 is currently regarded as a potent and selective inhibitor of hypoxia-inducible factor-
2α (HIF-2α), with potential antineoplastic activity. However, the membrane ion channels …