[HTML][HTML] JMCC Point-Counterpoint: What keeps us ticking, a funny current, a Calcium clock, or both?
EG Lakatta, D DiFrancesco - Journal of molecular and cellular …, 2009 - ncbi.nlm.nih.gov
About 50 years ago, pioneering work initiated by Silvio Weidmann and others applied the
Hodgkin-Huxley formalism of membrane excitation to interpret the cardiac electrical activity …
Hodgkin-Huxley formalism of membrane excitation to interpret the cardiac electrical activity …
Dynamic interactions of an intracellular Ca2+ clock and membrane ion channel clock underlie robust initiation and regulation of cardiac pacemaker function
VA Maltsev, EG Lakatta - Cardiovascular research, 2008 - academic.oup.com
For almost half a century it has been thought that the initiation of each heartbeat is driven by
surface membrane voltage-gated ion channels (M clocks) within sinoatrial nodal cells. It has …
surface membrane voltage-gated ion channels (M clocks) within sinoatrial nodal cells. It has …
Simulation of biochemical dynamics of and in fibroblast cell
Calcium dynamics is not only responsible for maintaining the framework and functions of the
cell but also plays a role in the dynamics of other biochemical systems in the cell …
cell but also plays a role in the dynamics of other biochemical systems in the cell …
Cellular nitric oxide synthesis is affected by disorders in the interdependent and dynamics during cystic fibrosis disease
AB Kothiya, N Adlakha - Journal of Biological Physics, 2023 - Springer
Abstract Calcium (C a 2+), inositol trisphosphate (IP 3), and nitric oxide (NO) signaling are
essential to maintain the structural integrity and physiological activity of fibroblast cells. The …
essential to maintain the structural integrity and physiological activity of fibroblast cells. The …
Impact of Interdependent Ca2+ and IP3 Dynamics On ATP Regulation in A Fibroblast Model
The vital participation of C a 2+ in human organ functions such as muscular contractions,
heartbeat, brain functionality, skeletal activity, etc, motivated the scientists to thoroughly …
heartbeat, brain functionality, skeletal activity, etc, motivated the scientists to thoroughly …
Model of calcium dynamics regulating ip3 and atp production in a fibroblast cell
Fibroblast cells are involved in the mechanism of growth and repair of tissue in human
organs. Calcium (Ca2+) signaling is essentially required to maintain the microstructure and …
organs. Calcium (Ca2+) signaling is essentially required to maintain the microstructure and …
Multiple Dynamical Mechanisms of Phase-2 Early Afterdepolarizations in a Human Ventricular Myocyte Model: Involvement of Spontaneous SR Ca2+ Release
Y Kurata, K Tsumoto, K Hayashi, I Hisatome… - Frontiers in …, 2020 - frontiersin.org
Early afterdepolarization (EAD) is known to cause lethal ventricular arrhythmias in long QT
syndrome (LQTS). In this study, dynamical mechanisms of EAD formation in human …
syndrome (LQTS). In this study, dynamical mechanisms of EAD formation in human …
Roles of sarcoplasmic reticulum Ca2+ cycling and Na+/Ca2+ exchanger in sinoatrial node pacemaking: Insights from bifurcation analysis of mathematical models
Y Kurata, I Hisatome… - American Journal of …, 2012 - journals.physiology.org
To elucidate the roles of sarcoplasmic reticulum (SR) Ca2+ cycling and Na+/Ca2+
exchanger (NCX) in sinoatrial node (SAN) pacemaking, we have applied stability and …
exchanger (NCX) in sinoatrial node (SAN) pacemaking, we have applied stability and …
Liénard-type chemical oscillator
We show that a class of arbitrary, autonomous kinetic equations in two variables describing
chemical and biochemical oscillations can be reduced to the form of a Liénard oscillator …
chemical and biochemical oscillations can be reduced to the form of a Liénard oscillator …
Effective Perturbations of the Amplitude, Gating, and Hysteresis of IK(DR) Caused by PT-2385, an HIF-2α Inhibitor
PT-2385 is currently regarded as a potent and selective inhibitor of hypoxia-inducible factor-
2α (HIF-2α), with potential antineoplastic activity. However, the membrane ion channels …
2α (HIF-2α), with potential antineoplastic activity. However, the membrane ion channels …