Involvement of inflammation and its resolution in disease and therapeutics
S Alfaro, V Acuña, R Ceriani, MF Cavieres… - International Journal of …, 2022 - mdpi.com
Inflammation plays a critical role in the response to and survival from injuries and/or
infections. It occurs in two phases: initiation and resolution; however, when these events do …
infections. It occurs in two phases: initiation and resolution; however, when these events do …
A New Experimental Model for Assessing Drug Efficacy against Trypanosoma cruzi Infection Based on Highly Sensitive In Vivo Imaging
The protozoan Trypanosoma cruzi is the causative agent of Chagas disease, one of the
world's major neglected infections. Although development of improved antiparasitic drugs is …
world's major neglected infections. Although development of improved antiparasitic drugs is …
Challenges in Chagas disease drug development
AF Francisco, S Jayawardhana, F Olmo, MD Lewis… - Molecules, 2020 - mdpi.com
The protozoan parasite Trypanosoma cruzi causes Chagas disease, an important public
health problem throughout Latin America. Current therapeutic options are characterised by …
health problem throughout Latin America. Current therapeutic options are characterised by …
Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage
AF Francisco, S Jayawardhana, MD Lewis, KL White… - Scientific Reports, 2016 - nature.com
The insect-transmitted protozoan parasite Trypanosoma cruzi is the causative agent of
Chagas disease, and infects 5–8 million people in Latin America. Chagas disease is …
Chagas disease, and infects 5–8 million people in Latin America. Chagas disease is …
Biological factors that impinge on Chagas disease drug development
Chagas disease is caused by infection with the insect-transmitted protozoan Trypanosoma
cruzi, and is the most important parasitic infection in Latin America. The current drugs …
cruzi, and is the most important parasitic infection in Latin America. The current drugs …
Pharmacokinetics and tissue distribution of benznidazole after oral administration in mice
L Perin, R Moreira da Silva, KS Fonseca… - Antimicrobial agents …, 2017 - Am Soc Microbiol
Specific chemotherapy using benznidazole (BNZ) for Chagas disease during the chronic
stage is controversial due to its limited efficacy and toxic effects. Although BNZ has been …
stage is controversial due to its limited efficacy and toxic effects. Although BNZ has been …
Infectious myocarditis: the role of the cardiac vasculature
L Woudstra, LJM Juffermans, AC van Rossum… - Heart Failure …, 2018 - Springer
Infectious myocarditis is the result of an immune response to a microbial infection of the
heart. The blood vessels of the heart, both the intramyocardial microvasculature and the …
heart. The blood vessels of the heart, both the intramyocardial microvasculature and the …
Vaccine-linked chemotherapy with a low dose of benznidazole plus a bivalent recombinant protein vaccine prevents the development of cardiac fibrosis caused by …
VM Dzul-Huchim, MJ Ramirez-Sierra… - PLoS Neglected …, 2022 - journals.plos.org
Background Chagas disease (CD) is caused by Trypanosoma cruzi and affects 6–7 million
people worldwide. Approximately 30% of chronic patients develop chronic chagasic …
people worldwide. Approximately 30% of chronic patients develop chronic chagasic …
[HTML][HTML] Low-dose benznidazole treatment results in parasite clearance and attenuates heart inflammatory reaction in an experimental model of infection with a highly …
Chagas disease, caused by Trypanosoma cruzi, is the main cause of dilated
cardiomyopathy in the Americas. Antiparasitic treatment mostly relies on benznidazole (Bzl) …
cardiomyopathy in the Americas. Antiparasitic treatment mostly relies on benznidazole (Bzl) …
Comparing in vivo bioluminescence imaging and the Multi-Cruzi immunoassay platform to develop improved Chagas disease diagnostic procedures and biomarkers …
AF Francisco, U Saade, S Jayawardhana… - PLoS neglected …, 2022 - journals.plos.org
Background Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and is
a serious public health problem throughout Latin America. With 6 million people infected …
a serious public health problem throughout Latin America. With 6 million people infected …