Inflammatory cell death induced by cytotoxic lymphocytes: a dangerous but necessary liaison

D de Miguel, A Ramirez‐Labrada, I Uranga… - The FEBS …, 2022 - Wiley Online Library
Cytotoxic lymphocytes (CLs), and more specifically Tc and NK cells, are the main executors
of cell death in the immune system, playing a key role during both immunosurveillance and …

Impaired Cytotoxic CD8+ T Cell Response in Elderly COVID-19 Patients

J Westmeier, K Paniskaki, Z Karaköse, T Werner… - MBio, 2020 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a T cell
response that most likely contributes to virus control in COVID-19 patients but may also …

[HTML][HTML] Cytotoxic CD4+ T cells in chronic viral infections and cancer

A Malyshkina, A Brüggemann, A Paschen… - Frontiers in …, 2023 - frontiersin.org
CD4+ T cells play an important role in immune responses against pathogens and cancer
cells. Although their main task is to provide help to other effector immune cells, a growing …

[HTML][HTML] Decoding the mechanisms of chimeric antigen receptor (CAR) T cell-mediated killing of tumors: insights from granzyme and Fas inhibition

MJ Montalvo, IN Bandey, A Rezvan, KL Wu… - Cell Death & …, 2024 - nature.com
Chimeric antigen receptor (CAR) T cell show promise in cancer treatments, but their
mechanism of action is not well understood. Decoding the mechanisms used by individual T …

[HTML][HTML] Host immune response against DENV and ZIKV infections

SD Sekaran, AA Ismail, G Thergarajan… - Frontiers in cellular …, 2022 - frontiersin.org
Dengue is a major public health concern, affecting almost 400 million people worldwide,
with about 70% of the global burden of disease in Asia. Despite revised clinical …

Lymphopenia with altered T Cell subsets in hospitalized COVID-19 patients in Pune, India

P Suryawanshi, B Takbhate, P Athavale, P Jali… - Viral …, 2023 - liebertpub.com
The cellular immune cell subsets affecting COVID-19 disease severity are being studied by
researchers from many countries. The current study was carried out to investigate the …

[HTML][HTML] Immunotherapy-induced cytotoxic T follicular helper cells reduce numbers of retrovirus-infected reservoir cells in B cell follicles

A Malyshkina, W Bayer, P Podschwadt, L Otto… - PLoS …, 2023 - journals.plos.org
Antiretroviral therapy (ART) transformed HIV from a life-threatening disease to a chronic
condition. However, eliminating the virus remains an elusive therapy goal. For several …

T cell reprogramming against cancer

SG Katz, PM Rabinovich - Cell Reprogramming for Immunotherapy …, 2020 - Springer
Advances in academic and clinical studies during the last several years have resulted in
practical outcomes in adoptive immune therapy of cancer. Immune cells can be programmed …

[HTML][HTML] Regulatory T cells in retroviral infections

KJ Hasenkrug, CA Chougnet, U Dittmer - PLoS pathogens, 2018 - journals.plos.org
Tight regulation of immune responses is not only critical for preventing autoimmune
diseases but also for preventing immunopathological damage during infections in which …

Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity

U Dittmer, K Sutter, G Kassiotis… - FEMS microbiology …, 2019 - academic.oup.com
ABSTRACT Approximately 4.4% of the human genome is comprised of endogenous
retroviral sequences, a record of an evolutionary battle between man and retroviruses. Much …