Mammals are often considered to be masters of homeostasis, with the ability to maintain a
constant internal milieu, despite marked changes in the environment; however, many …

Food shortages represent a common challenge for most animal species. As a consequence,
many have evolved metabolic strategies encompassing extreme starvation-resistance …

Revealing the mechanisms underlying the reversible physiology of hibernation could have
applications to both human and animal health as hibernation is often associated with …

Mammals maintain a constant warm body temperature, facilitating a wide variety of
metabolic reactions. Mammals that hibernate have the ability to slow their metabolism, which …

Comparative analyses of bats indicate that hibernation is associated with increased
longevity among species. However, it is not yet known if hibernation affects biological …

Brown adipose tissue (BAT) is a unique thermogenic tissue in mammals that rapidly
produces heat via nonshivering thermogenesis. Small mammalian hibernators have evolved …

Background In mammals, the hibernating state is characterized by biochemical adjustments,
which include metabolic rate depression and a shift in the primary fuel oxidized from …

Tissue-resident stem cells may enter a dormant state, also known as quiescence, which
allows them to withstand metabolic stress and unfavorable conditions. Similarly, hibernating …

Some vertebrates evolved to have a remarkable capacity for anatomical and physiological
plasticity in response to environmental challenges. One example of such plasticity can be …

Increasing non‐shivering thermogenesis (NST), which expends calories as heat rather than
storing them as fat, is championed as an effective way to combat obesity and metabolic …