Renal failure remains a principal cause of morbidity for patients with multiple myeloma.
Once reversible factors such as hypercalcemia have been corrected, the most common …

Light chain cast nephropathy (LCCN) is a leading cause of acute kidney injury (AKI) in
patients with multiple myeloma (MM) and is now defined as a myeloma defining event. While …

Symptomatic multiple myeloma is commonly complicated by acute kidney injury through
various mechanisms. The most frequent is the precipitation of monoclonal free light chains …

The role of thalidomide, bortezomib and lenalidomide in multiple myeloma patients
presenting with renal impairment was evaluated in 133 consecutive newly diagnosed …

Renal impairment (RI) is seen in over a quarter of patients with newly diagnosed multiple
myeloma (NDMM). It is not clear if reversal of RI improves the outcome to that expected for …

Abstract STAT3–STAT3 dimerization, which involves reciprocal binding of the STAT3-SH2
domain to phosphorylated tyrosine-705 (Y-705), is required for STAT3 nuclear translocation …

The tubular nephron is responsible for reabsorption and catabolism of filtered low molecular
weight proteins that include Ig free light chains. In the setting of a plasma cell dyscrasia …

Multiple Myeloma is a plasma cell proliferative disorder that commonly involves the kidney.
Renal impairment is a serious complication during the course of the disease that is …

Because of the less-than-robust response to therapy and impact on choice of optimal
chemotherapy and prognosis, chronic kidney disease has drawn attention in the treatment of …

In the last decade, the introduction of the serum-free light-chain (sFLC) assay has been an
important advance in the diagnosis and management of plasma cell dyscrasias, particularly …