New approaches to tackle a rising problem: Large-scale methods to study antifungal resistance

PC Després, RS Shapiro, CA Cuomo - Plos Pathogens, 2024 - journals.plos.org
Fungi are important pathogens responsible for millions of infections and deaths every year
through disease and food insecurity [1, 2]. Drug-resistant fungi are especially concerning …

Impact of pathogen genetics on clinical phenotypes in a population of Talaromyces marneffei from Vietnam

P Sephton-Clark, T Nguyen, NT Hoa, P Ashton… - Genetics, 2023 - academic.oup.com
Talaromycosis, a severe and invasive fungal infection caused by Talaromyces marneffei, is
difficult to treat and impacts those living in endemic regions of Southeast Asia, India, and …

Genetic diversity of human fungal pathogens

J Freese, S Beyhan - Current clinical microbiology reports, 2023 - Springer
Abstract Purpose of Review Fungi represent a central yet often overlooked domain of
clinically relevant pathogens that have become increasingly important in human disease …

The buoyancy of cryptococcal cells and its implications for transport and persistence of Cryptococcus in aqueous environments

IA Jimenez, PR Stempinski, Q Dragotakes… - mSphere, 2024 - journals.asm.org
Cryptococcus is a genus of saprophytic fungi with global distribution. Two species
complexes, Cryptococcus neoformans and Cryptococcus gattii, pose health risks to humans …

Growth on Douglas fir media facilitates Cryptococcus virulence factor production and enhances fungal survival against environmental and immune stressors

PR Stempinski, SD Greengo, A Casadevall - Medical mycology, 2024 - academic.oup.com
The yeasts Cryptococcus neoformans and Cryptococcus gattii are fungal pathogens that can
be isolated from the environment, including the surfaces of many plants. Cryptococcus gattii …

Molecular characterization of clinical and environmental isolates from the Cryptococcus neoformans/C. Gattii species complexes of Maceió, Alagoas, Brazil

DL de Holanda Fonseca, DMW Silva… - Brazilian Journal of …, 2024 - Springer
Cryptococcosis is one of the major life-threatening opportunistic/systemic fungal diseases of
worldwide occurrence, which can be asymptomatic or establish pneumonia and …

Caught red feathered: infection from cockatoo to human and mice reveals genetic plasticity of Cryptococcus neoformans during mammalian passage

DG Cohen, RA Wingert - Tissue Barriers, 2024 - Taylor & Francis
The fungus Cryptococcus neoformans is pervasive in our environment and causes the
infectious disease cryptococcosis in humans, most commonly in immunocompromised …

Distinct pathways of adaptive evolution in Cryptococcus neoformans reveal a point mutation in adenylate cyclase with drastic tradeoffs for pathogenicity

ZA Hilbert, KY Chung, JM Bednarek, MW Schwiesow… - bioRxiv, 2022 - biorxiv.org
Pathogenic fungi populate a wide range of environments and infect a diversity of host
species. Despite this substantial biological flexibility, the impact of interactions between …

Commonalities and differences in the Cryptococcus neoformans response to ingestion by protozoal and mammalian phagocytic cells suggests host cell metabolism as …

Q Dragotakes, E Jacobs, G Gerbig, S Greengo… - bioRxiv, 2024 - biorxiv.org
The outcome of the interaction between Cryptococcus neoformans and infected hosts can
be determined by whether the fungal cell survives ingestion by phagocytic cells. This applies …

Host-Microbe Interactions Between Cryptococcus neoformans and Phagocytes

SD Greengo - 2022 - jscholarship.library.jhu.edu
The result of infection by the pathogenic fungus Cryptococcus neoformans is highly
dependent on the outcome of interactions between yeasts and the cells of the host immune …