While HIV-1 infection of target cells with cell-free viral particles has been largely
documented, intercellular transmission through direct cell-to-cell contact may be a …

HIV-1 spreads through contacts between infected and target cells. Polarized viral budding at
the contact site forms the virological synapse. Additional cellular processes, such as …

Human immunodeficiency virus type 1 (HIV-1) interactions with myeloid dendritic cells (DCs)
can result in virus dissemination to CD4+ T cells via a trans infection pathway dependent on …

Macrophage infection is considered to play an important role in HIV-1 pathogenesis and
persistence. Using a primary cell-based coculture model, we show that monocyte-derived …

B cells produce a plethora of anti-HIV antibodies (Abs) but only few of them exhibit
neutralizing activity. This was long considered a profound limitation for the enforcement of …

Myeloid dendritic cells (DCs) can capture HIV-1 via the receptor CD169/Siglec-1 that binds
to the ganglioside, GM3, in the virus particle membrane. In turn, HIV-1 particles captured by …

Cell-to-cell spread of human immunodeficiency virus (HIV-1) between immune cells was first
observed over 20 years ago. During this time, the question of whether this infection route …

HIV mainly targets CD4+ T cells, from which Th17 cells represent a major cell type,
permissive, and are capable of supporting intracellular replication at mucosal sites. Th17 …

HIV antibody (Ab) functions capable of preventing mucosal cell-free or cell-to-cell HIV
transmission are critical for the development of effective prophylactic and therapeutic …

All human immunodeficiency virus type 1 (HIV-1)–infected inocula, such as genital
secretions, breast milk, and blood, contain both cell-free virus and infected cells. The relative …