Activation mechanisms for organometallic anticancer complexes

AM Pizarro, A Habtemariam, PJ Sadler - Medicinal Organometallic …, 2010 - Springer
Organometallic complexes offer potential for design as anticancer drugs. They can act as
inert scaffolds and specifically inhibit enzymes such as kinases, or as pro-drugs which …

Upconverting nanoparticles for the near infrared photoactivation of transition metal complexes: new opportunities and challenges in medicinal inorganic …

E Ruggiero, S Alonso-de Castro, A Habtemariam… - Dalton …, 2016 - pubs.rsc.org
Upconverting nanoparticles for the near infrared photoactivation of transition metal complexes:
new opportunities and challenges in medicinal inorgani ... - Dalton Transactions (RSC …

Construction of emissive ruthenium (II) metallacycle over 1000 nm wavelength for in vivo biomedical applications

Y Xu, C Li, S Lu, Z Wang, S Liu, X Yu, X Li… - Nature …, 2022 - nature.com
Although Ru (II)-based agents are expected to be promising candidates for substituting Pt-
drug, their in vivo biomedical applications are still limited by the short excitation/emission …

[HTML][HTML] Advances in the design of organometallic anticancer complexes

P Zhang, PJ Sadler - Journal of Organometallic Chemistry, 2017 - Elsevier
Organometallic complexes containing ligands such as CO, carbenes, alkyls, phenyls, π-
bound alkynes, alkenes, cyclopentadienyls and arenes possess properties which have often …

Designing organometallic compounds for catalysis and therapy

AL Noffke, A Habtemariam, AM Pizarro… - Chemical …, 2012 - pubs.rsc.org
Bioorganometallic chemistry is a rapidly developing area of research. In recent years
organometallic compounds have provided a rich platform for the design of effective catalysts …

An integrin-targeted photoactivatable Pt (IV) complex as a selective anticancer pro-drug: synthesis and photoactivation studies

A Gandioso, E Shaili, A Massaguer, G Artigas… - Chemical …, 2015 - pubs.rsc.org
A new anticancer agent based on the conjugation of a photoactivatable Pt (IV) pro-drug to a
cyclic RGD-containing peptide is described. Upon visible light irradiation, phototoxicity was …

Structurally strained half-sandwich iridium (III) complexes as highly potent anticancer agents

AC Carrasco, V Rodríguez-Fanjul… - Journal of Medicinal …, 2020 - ACS Publications
Six complexes of formula [Ir (η5: κ1-C5Me4CH2py)(C, N)] PF6, where C5Me4CH2py is 2-((2,
3, 4, 5-tetramethylcyclopentadienyl) methyl) pyridine, and C, N is 2-phenylpyridine (1), 7, 8 …

Detailed account on activation mechanisms of ruthenium coordination complexes and their role as antineoplastic agents

M Pal, U Nandi, D Mukherjee - European Journal of Medicinal Chemistry, 2018 - Elsevier
Ruthenium (Ru) complexes are known for their promising anticancer activity presumably
due to octahedral coordination geometry, slow ligand exchange rate, the range of different …

The development of Ru (II)-based photoactivated chemotherapy agents

Y Chen, L Bai, P Zhang, H Zhao, Q Zhou - Molecules, 2021 - mdpi.com
Photoactivated chemotherapy (PACT) is a novel cancer treatment method that has drawn
increasing attention due to its high selectivity and low side effects by spatio-temporal control …

Beyond photodynamic therapy: light-activated cancer chemotherapy

F Reeæ# 159; ing, W Szymanski - Current Medicinal Chemistry, 2017 - benthamdirect.com
Background: Cancer chemotherapy is limited by severe side effects due to unspecific
cytotoxic activity of currently used therapeutics. In order to minimize these unwanted effects …