Immune response following traumatic spinal cord injury: Pathophysiology and therapies

RC Sterner, RM Sterner - Frontiers in immunology, 2023 - frontiersin.org
Traumatic spinal cord injury (SCI) is a devastating condition that is often associated with
significant loss of function and/or permanent disability. The pathophysiology of SCI is …

Acute spinal cord injury: Pathophysiology and pharmacological intervention

Y Zhang, A Al Mamun, Y Yuan… - Molecular …, 2021 - spandidos-publications.com
Spinal cord injury (SCI) is one of the most debilitating of all the traumatic conditions that
afflict individuals. For a number of years, extensive studies have been conducted to clarify …

The search for translational pain outcomes to refine analgesic development: Where did we come from and where are we going?

R González-Cano, Á Montilla-García… - Neuroscience & …, 2020 - Elsevier
Pain measures traditionally used in rodents record mere reflexes evoked by sensory stimuli;
the results thus may not fully reflect the human pain phenotype. Alterations in physical and …

Grimace scale, burrowing, and nest building for the assessment of post-surgical pain in mice and rats—A systematic review

K Aulehner, C Leenaars, V Buchecker… - Frontiers in Veterinary …, 2022 - frontiersin.org
Several studies suggested an informative value of behavioral and grimace scale parameters
for the detection of pain. However, the robustness and reliability of the parameters as well as …

[HTML][HTML] Established and emerging therapies in acute spinal cord injury

R Gadot, DN Smith, M Prablek, JK Grochmal… - Neurospine, 2022 - ncbi.nlm.nih.gov
Acute spinal cord injury (SCI) is devastating for patients and their caretakers and has an
annual incidence of 20–50 per million people. Following initial assessment with appropriate …

Refinement of the motorised laminectomy-assisted rat spinal cord injury model by analgesic treatment

H Vijayakumar Sreelatha, H Palekkodan… - Plos one, 2024 - journals.plos.org
Usage and reporting of analgesia in animal models of spinal cord injury (SCI) have been
sparse and requires proper attention. The majority of experimental SCI research uses rats as …

A new anesthetic protocol to medullary nerve roots access in rats

DR Santos, RKC Teixeira, NP Araújo… - Acta Cirúrgica …, 2021 - SciELO Brasil
Purpose: To describe a new anesthetic protocol medullary and nerve roots access and in
Rattus norvegicus. Methods: Seventy female Wistar rats (n= 70) were used. The animals …

Management strategies for spinal cord injury pain updated for the twenty-first century

E Shaw, M Saulino - Physical Medicine and Rehabilitation …, 2020 - pmr.theclinics.com
Traumatic spinal cord injury (SCI) often results in several life-altering impairments, including
paralysis, sensory loss, and neurogenic bowel/bladder dysfunction. Some of these SCI …

[PDF][PDF] A Review of Pharmacological and Cell-based Therapies in Spinal Cord Injury

S Amanollahi, H Kazemi Mehrjerdi - Journal of Cell and Molecular …, 2023 - jcmr.um.ac.ir
Spinal cord injury (SCI) is a severe central nervous system trauma (CNS) that has two
primary and secondary phases. The initial phase, which is irreversible, causes nerve tissue …

[PDF][PDF] Evidenz-basierte Belastungseinschätzung bei Labornagern in der post-operativen Phase und bei kabel-gebundener Ableitung

K Aulehner - 2022 - edoc.ub.uni-muenchen.de
Die aktuelle weltweite pandemische Situation im Rahmen von COVID-19 (Coronavirus
Disease 2019) hat die Relevanz von Tierversuchen verdeutlicht. Besonders in der …